+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Quality of life in renal transplant recipients following conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium

, : Quality of life in renal transplant recipients following conversion from mycophenolate mofetil to enteric-coated mycophenolate sodium. Transplantation Proceedings 39(7): 2179-2181

Introduction. Tolerance to immunosuppresant treatment has considerable impact on adherence to therapy and on the outcome of renal transplantation. Recent data indicate better gastrointestinal tolerance to enteric-coated mycophenolate sodium (EC-MPS) than to the classic mycophenolate mofetil (MMF) formulation. Aim. This study assessed the effect of conversion therapy from MMF to EC-MPS on gastrointestinal tolerance and quality of life in renal transplant recipients.Methods. This open observational study analyzed the outcomes of conversion from MMF to EC-MPS among renal transplant patients with gastrointestinal complaints. At baseline (B) and at 8 weeks postconversion patients were assessed by the Gastrointestinal Quality of Life Index (GIQLI) questionnaire as well as by clinical evaluation (acute rejection, infection) and analytical determinations.Results. We analyzed 18 recipients of cadaveric renal transplants of mean age of 54 9 years including 61% men and one retrasplant. Our patients had stable renal function with mean creatinine of 1.9 +/- 0.7 mg/dL. Baseline treatment included cyclosporine-MMF-prednisone (33%) or FK-MMF-prednisone (66%). Bioequivalent conversion was carried out at 50 +/- 29 months posttransplantation. Conversion to EC-MPS resulted in an improvement in overall quality of life (total score: baseline 106.61. vs 8 weeks 116.89; P < .01). Improvements were observed in the following GIQLI subscales: gastrointestinal symptoms (3.12 vs 3.48, P < .001), physical function (2.54 vs 2.76, P = .003), medical treatment (2.17 vs 2.50, P = .031), and emotion (3.08 vs 3.39, P = .001). No changes were observed in the social function subscale. The hemogram and renal function remained stable; there were no episodes of rejection or infection.Conclusion. Conversion from MMF to an EC-MPS formulation was associated with improvements in gastrointestinal complaints and quality of life among renal transplant recipients.


PMID: 17889130

DOI: 10.1016/j.transproceed.2007.07.012

Other references

Poisel R.; Steger W.; Zeitler A., 1991: Stability investigations of competent rock masses lying on an incompetent base. Proceedings of the Congress of the International Society for Rock Mechanics 7: 939-944

Wollenweber G.Y., 1982: Flavonoid esters from the fern notholaena neglecta. The fern N. neglecta produces a lipophilic farinose frond exudate that is composed of flavonoid aglycones. A major constituent is one of the very rare flavonol esters, 7-O-methyl 8-acetoxy-galangin. Traces of the correpsonding butyryl derivative a...

Jelenko, C.; Buxton, R.W., 1966: Studies in burns. II. The role of hydrational status on water loss from the body surface. American Surgeon 32(11): 781-793

Anonymous, 2011: Regional differences in the care of acute stroke patients. Considerable regional differences exist in the treatment of patients with acute cerebral infarction. This is the finding presented by Erwin Stolz and his co-authors in the current issue of Deutsches Aerzteblatt International.

Varnier O.; Lillo F.; Cao Y.; Concedi D.; Greco G.M.; P.; Gandolfo A.M.; Loy A.; D.L.o P.; Terragna A.; Mangiante P.E., 1992: Urine and saliva alternative specimens for hiv 1 antibody testing. Melica, F (Ed ) Aids And Human Reproduction; 1st International Symposium on Aids And Reproduction, Genoa, Italy, December 12-15, 1990 Xi+195p S Karger Ag: Basel, Switzerland; New York, New York, Usa Illus Maps 113-118

Ferguson, P.R.binson, R.; Press, M.; Lee, J., 1984: Element concentrations in five Sphagnum species in relation to atmospheric pollution. Journal of bryology3(1): 107-114

Sasturain, J.; Schwedt, G., 1993: Development of an ion chromatography process for application in a waterworks. Hochmueller, Kurt [Editor], Bernard, Braukmann [Editor], Klaus, Haberer [Editor], Brigitte, Hamburger [Editor], Paul, Koppe [Editor] [Water] Vom Wasser : 221-233

Espie, C.A.; Broomfield, N.M.; MacMahon, K.M.A.; Macphee, L.M.; Taylor, L.M., 2006: The attention-intention-effort pathway in the development of psychophysiologic insomnia: a theoretical review. Psychophysiologic insomnia (PI) is the most common form of persistent primary insomnia. Its 'behavioral phenotype', comprising elements such as conditioned arousal, sleep-incompatible behavior and sleep preoccupation, has not changed mar...

Krebs, D.A., 2005: Reflections of a caregiver. American Journal of Alzheimer's Disease and Other Dementias 20(3): 191-192

Hussain, M.; Leach, A.; Hardy, C., 2006: A refined method of restraint for dogs used in inhalation studies. Animal Technology and Welfare 5(3): 179-181