geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Quality of life in survivors of multiple primary cancers compared with cancer survivor controls


, : Quality of life in survivors of multiple primary cancers compared with cancer survivor controls. Cancer 110(9): 2101-2109

BACKGROUND. Cancer survivors may develop additional cancers after their first diagnosis, but to the authors' knowledge the quality of life (QOL) consequences of a second cancer are not known. The current study assessed QOL and its correlates after a second cancer diagnosis.METHODS. QOL was compared between 487 survivors of second-order and higher-order primary cancer diagnoses, and a matched group of 589 survivors of a single cancer diagnosis. Outcome measures included standardized question-naires that assessed depressive symptoms, perceived stress, vitality, post-traumatic growth, existential well-being, sexual adjustment, and global QOL.RESULTS. Survivors of multiple primary cancer diagnoses had significantly lower global QOL (t (792) = 5.42; P <.001), vitality (Student t test [t] (794) = 2.41; P <.01), and existential well-being (t (775) = 2.78; P <.01), and higher intrusive stress symptoms (t (775) = -1.93; P <.05). Controlling for demographic, medical, and trait-like psychosocial characteristics (eg, optimism and resilience), having multiple primary cancer diagnoses explained small, although significant, variances in global QOL (coefficient of determination [R-2] =.04; P <.001), vitality (R-2 =.01; P <.05), and existential well-being (R-2 =.01; P <.05), with patients in the multiple primary cancer group faring worse on all of these measures.CONCLUSIONS. The results of the current study suggest that the typical survivor of multiple primary cancers experiences modest but lasting QOL deficits.

US$19.90

PMID: 17823915

DOI: 10.1002/cncr.23005


Other references

Svajger, U.; Anderluh, M.; Jeras, M.; Obermajer, N., 2010: C-type lectin DC-SIGN: an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunity. The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells (APCs), the dendritic cells (DCs). In recent years,...

Marsh, A.; Christensen, D.; Sanchez, T.; Mickelsen, O.C.affee, F., 1989: Nutrient similarities and differences of older lacto-ovo-vegetarian and omnivorous women. The dietary intakes of ten post-menopausal lacto-ovo-vegetarian women were compared with those of a similar group of ten omnivorous women. The seven-day food and beverage records showed significant dietary differences in their calcium to phosphoru...

Heber, U.; Pon, N.G.; Heber, M., 1963: Localization of carboxydismutase and triosephosphate dehydrogenases in chloroplasts. A quantitative method has been developed to calculate the distribution in the cell of soluble enzymes from data on enzyme activities in different cell fractions and from the protein distribution within the cell. Chloroplasts were isolated in a non...

Farquhar Oswald C., 1982: Leakage of compressed air from a storage cavern in hard rock at Ragged Chutes, Cobalt, Ontario. Pages 293-310 1982

Bogdan G?dek, 2012: Debris slopes ventilation in the periglacial zone of the Tatra Mountains Poland and Slovakia The indicators. This paper examines environmental indicators of debris slopes ventilation in the periglacial zone of the Tatra Mountains. There were analysed geomorphological and meteorological influences on a ground surface temperature anomaly, hoarfrost, air ve...

Bodendiek, S.B.; Mahieux, Cédrick.; Hänsel, W.; Wulff, H., 2008: 4-Phenoxybutoxy-substituted heterocycles--a structure-activity relationship study of blockers of the lymphocyte potassium channel Kv1.3. The voltage-gated potassium channel Kv1.3 constitutes an attractive pharmacological target for the treatment of effector memory T cell-mediated autoimmune diseases such as multiple sclerosis and psoriasis. Using 5-methoxypsoralen (5-MOP, 1), a com...

Fayzullin R.M., 1968: Gold-bearing quartzites of the Baley region, eastern Transbaikalia. Noncommercial, Paleozoic, gold from Carboniferous granitic intrusive, associated younger gold deposits connected with Jurassic-Cretaceous volcanism, southeast Siberia.

Rubin, L.G.; Schaffner, W., 2014: Clinical practice. Care of the asplenic patient. New England Journal of Medicine 371(4): 349-356

Hisaoka, M.; Furuta, A.; Rikimaru, S., 1993: Sclerosing fibrous tumor of the cauda equina: a fibroblastic variant of peripheral nerve tumors?. The case of a 43-year-old man with an unusual mesenchymal tumor of the cauda equina is presented. A well-circumscribed firm tumor was found in the lower spinal canal at L1 level. Although a nerve root was involved, the adjacent dura mater or filum...

Hiromoto, T.; Warkentin, E.; Moll, J.; Ermler, U.; Shima, S., 2009: The crystal structure of an [Fe]-hydrogenase-substrate complex reveals the framework for H2 activation. Angewandte Chemie 48(35): 6457-6460