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Quality of life in systemic sclerosis: psychometric properties of the World Health Organization Disability Assessment Schedule II

, : Quality of life in systemic sclerosis: psychometric properties of the World Health Organization Disability Assessment Schedule II. Arthritis and Rheumatism 59(2): 270-278

Objective. To determine the validity of the World Health Organization Disability Assessment Schedule II (WHODAS II) in systemic sclerosis (SSc).Methods. Patients enrolled in the Canadian Scleroderma Research Group registry participated in a standardized evaluation and completed the WHODAS II. Criterion validity was assessed by comparing the WHODAS II with the Medical Outcomes Study Short Form 36 (SF-36), construct validity was assessed by examining how it relates to common measures of outcome in SSc, and discriminative validity was assessed by examining how it distinguishes patients with more severe disease from those with less severe disease.Results. A total of 402 patients with SSc were included (mean +/- SD age 55 +/- 13 years, 87% women, mean +/- SD disease duration 11 +/- 9 years). The mean SD WHODAS II score was 24.6 +/- 17.4, and the greatest impairments were in life activities and mobility. There were moderate to good correlations between the WHODAS II and the SF-36 Physical Component Summary, score (r = -0.44), the SF-36 Mental Component Summary score (r = -0.41), and measures of function (r = 0.54), depression (r = 0.44), pain (r = 0.40), and fatigue (r = -0.49, P < 0.0001 for all). The WHODAS II was able to consistently distinguish patients with milder disease from those with more severe disease.Conclusion. The WHODAS II had good psychometric properties in patients with SSc and should be considered a valid measure of health-related quality of life in SSc.


PMID: 18240187

DOI: 10.1002/art.23343

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McNamee, C.E.; Pyo, N.; Higashitani, K., 2006: Atomic force microscopy study of the specific adhesion between a colloid particle and a living melanoma cell: Effect of the charge and the hydrophobicity of the particle surface. We investigated the effect of the charge and the hydrophobicity of drug delivery system ( DDS) carriers on their specificity to living malignant melanoma B16F10 cells with the atomic force microscope. To model various nanoparticle DDS carriers, we...

Gee, A.C., 1946: Control of infectious diseases; notification. Nursing Mirror and Midwives Journal 83: 317-317

Wojcicki, Z., 1984: Problems of mechanization in the crop production in Poland. Zeszyty problemowe postepow nauk rolniczych: 95) 157-176

Sá de São José, A.; Miyazaki, N.Hirome.T.; Hirata, R.; Mattos-Guaraldi, A.Luiza.; Nagao, P.Emy., 2006: Intracellular viability in human non-polarized respiratory epithelial 16 HBE 14o- cells by group B Streptococcus serotype III clinical isolates presenting 162-kb and 183-kb virulence markers. Group B streptococci (GBS), mainly serotype III, are the major cause of neonatal pneumonia, sepsis and meningitis. Virulence potential of GBS strains may determine the outcome of host colonization or infection. Because the lung constitutes a first...

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Pestarino M., 1989: Occurrence of immunoreactive neuropeptide y like peptides in a protochordate. General & Comparative Endocrinology 74(2): 242

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