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Recent advances in the study of cleavable PEG-lipid derivatives modifying liposomes


, : Recent advances in the study of cleavable PEG-lipid derivatives modifying liposomes. Yao Xue Xue Bao 43(1): 18-22

Polyethylene glycol (PEG) lipid derivatives could increase the stability of liposomes in vivo and in vitro and prolong the circulation time of liposomes in vivo. However, the chemical bond between PEG and lipid was so stable that liposomes modified with traditional PEG-lipid derivatives could not release their contents at targeted tissue immediately and the pharmacodynamic effect was reduced. The concept of cleavable PEG-lipid was raised in recent years and these PEG-lipid derivatives could break under physiological or pathological condition. The cleavable PEG-lipid derivatives could prolong the circulation time of liposomes, and after arriving at targeted location, PEG fragment had cleaved from the surface of liposomes, so liposomes could bind with pathological cells and release contents into cells. Removal of the protective polymer layer is necessary once the liposome close to the tumour to allow to fuse and release drug. Attempts have been made to increase the circulation time and reconstitute the cellular affinity of liposomes by incorporating PEG-lipid derivatives. This review focused on the kinds of cleavable PEG-lipid derivatives, types of cleavage, the application feature to liposomes and the advantages and localizations.

US$29.90

PMID: 18357726


Other references

Zhu Zhongde; Wang Peirong; Liu Bingli; L.X.angming; Zhao Hong, 1995: Study of oil seepages in the Lower Ordovician of Yichang, Hubei, China. Jianghan Shiyou Xueyuan Xuebao = Journal of the Jianghan Petroleum Institute: , Pages 21-25. 1995.

Reva, Va, 1977: Effect of maturation stage on the content of lysine and tryptophan in maize seed. Izvestiia Akademii nauk Moldavskoi SSR: seriia biologicheskikh i khimicheskikh nauk: 90-91

Schurman, D.J.; Mirra, J.; Ding, A.; Nagel, D.A., 1977: Experimental E. coli arthritis in the rabbit. A model of infectious and post-infectious inflammatory synovitis. Rabbit knee joints challenged with E. coli 06 underwent a self-limited infection lasting several weeks followed by a prolonged post-infectious inflammatory arthritis. The E. coli used did not possess collagenolytic activity nor did a variety of co...

Kaminski, K.A.; Dziemidowicz, M.; Litvinovich, S.; Bonda, T.; Ptaszynska, K.; Kozuch, M.; Taranta, A.; Musial, W.J.; Winnicka, M.M., 2012: Interleukin 6 is not necessary for STAT3 phosphorylation and myocardial hypertrophy following short term beta-adrenergic stimulation. In recent years several reports have suggested involvement of interleukin 6 (IL-6) in beta-adrenergic effects on myocardium, particularly in enhancement of STAT3 phosphorylation (downstream signal transducer of IL-6). Here we present a study of is...

Went, A.E.J., 1958: Salmon movements around Ireland. VIII. From drift nets along the coast of County Donegal (1953-1957). Proceedings of the Royal Irish Academy, 59B 205-212

E.Samragy Y.A., 1988: The manufacture of zabady from goat milk. Goat milk was used to manufacture Egyptian fermented milk "zabady" or "zabadi" which is similar to yoghurt, but is usually made from buffalo milk, cow milk or a mixture of both. Goat milk zabady was evaluated using chemical, mi...

Harr, J.; Higgins, S.; Russell, P., 2002: Characteristics of families enrolled in an isolated, mountain Head Start program: managing social capital. The purpose of this exploratory, descriptive study was to identify the characteristics of families who chose to enroll their children in a Head Start program. Twenty families were asked questions about their level of education, financial assistanc...

Karamysheva, Z.N.; Ksenzenko, V.N.; Golubev, V.I.; Ratner, E.N.; Tikhomirova, L.P., 1993: Characteristics of viruses in the BKM Y-2700 mycocinogenic strain of Cystofilobasidium bisporidii yeasts. Doklady Akademii Nauk 331(3): 376-378

Rosenthal, H.; Hansen, P.-Diedrich. von Westernhagen, H.; Gordin, H.; Diamond, A., 2004: Prof Dr Volkert Dethlefsen - In memoriam. Journal of Applied Ichthyology. August; 204: 241-242

Beskaravainaya, M.A., 1971: The drought resistance of certain exotic trees and shrubs on the south Crimean coast. The drought resistance of 30 ornamental species grown in the Nikita Botanic Garden was studied and the water-retaining capacity of the leaves during the summer was recorded. The species were classified into 3 groups on the basis of these results.