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Time-dependent, exofocal alterations in the lateral geniculate nucleus following retinal damage in mice


, : Time-dependent, exofocal alterations in the lateral geniculate nucleus following retinal damage in mice. Yakugaku Zasshi 127(Suppl. 3): 126-128

Intravitreal injection of N-methyl-D-aspartate (NMDA) into the left eye induced retinal damage at 1 day after the injection. At 7 days after the injection, atrophy of the optic tract was observed on the contralateral side, but not on the ipsilateral side. Neuronal nuclear specific protein (NeuN)-immunostained neurons were decreased in number in the contralateral dorsal LGN (dLGN) and contralateral ventral LGN-lateral (vLGN-1) at 90 and 180 days, respectively, after the injection, and cell-size was decreased in the contralateral vLGN-1 and contralateral dLGN at 7 and 30 days, respectively. Furthermore, expressions of glial fibrillary acid protein (GFAP) in the contralateral dLGN and contralateral vLGN-1 were increased at 7 and 30 days, respectively, and those of brain-derived neurotrophic factor (BDNF) were increased at 30 and 90 days in the contralateral dLGN and at 7 and 30 days in the contralateral vLGN-1. All NeuN-positive neuronal cells exhibited BDNF, whereas only some GFAP-positive astroglial cells exhibited BDNF. However, the ventral LGN-medial (vLGN-m) and ipsilateral LGN displayed no morphological changes related to NeuN, GYAP, and BDNP immunchistochemistry. Taken together, these results indicate that time-dependent and exofocal alterations occurred after the NMDA injection along the retinogeniculate pathway (from retina to LGN), and that the degree of damage in the LGN was region-dependent. In addition, the increased expressions of GFAP and BDNF in the damaged regions may play some roles in the retrograde cell-death mechanism of the LGN.

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