geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

An FMRI auditory oddball study of combined-subtype attention deficit hyperactivity disorder


, : An FMRI auditory oddball study of combined-subtype attention deficit hyperactivity disorder. American Journal of Psychiatry 164(11): 1737-1749

Objective: Studies of attention deficit hyperactivity disorder (ADHD) have reliably found reduced amplitude event-related potentials (ERPs) measuring attention-related brain function, indicating impairment in the brain's ability to automatically orient attention to odd or novel environmental stimuli and to represent that information in working memory. However, the relationship between abnormal neurocognition and dysfunction in specific brain regions in ADHD remains unclear.Method: The authors used functional magnetic resonance imaging (WRI) to identify brain regions with abnormal hemodynamic activity during processing of target and novelty oddball stimuli that engage attention. Forty-six boys 11-18 years of age participated in the study, including 23 diagnosed as having ADHD with hyperactivity and impulsivity (combined type) and 23 demographically matched control subjects. Event-related WRI data were collected while partici- pants performed a three-stimulus auditory oddball task. Hemodynamic activity was compared between ADHD participants and control subjects in brain regions previously linked to P3 ERPs.Results: Participants with ADHD showed deficits in brain activity elicited by infrequent attentionally engaging stimuli in regions associated with attentional orienting and working-memory cognitive processes. These deficits co-occurred with highly variable and slow task performance.Conclusions: This study links ADHD attentional orienting and working-memory deficits to dysfunction in specific cortical brain regions. The results indicate that ADHD pathophysiology impairs brain systems that are important for allocating attention and using cognitive representations to guide cognition and behavior. Attention-related neural dysfunction is thus an important factor to consider in neurobiological theories of ADHD.

US$19.90

PMID: 17974940

DOI: 10.1176/appi.ajp.2007.06050876


Other references

Clavaguera, S.; Carella, A.; Caillier, L.; Celle, C.; Pécaut, J.; Lenfant, Séphane.; Vuillaume, D.; Simonato, J-Pierre., 2010: Sub-ppm detection of nerve agents using chemically functionalized silicon nanoribbon field-effect transistors. Angewandte Chemie 49(24): 4063-4066

Lynn, J.E.; Mcnutt, S.H.; Casida, L.E., 1966: Effects of intrauterine bacterial inoculation and suckling on the bovine corpus luteum and uterus. Persistenee of corpora lutea induced in cows postpartum by injection of gonadotropin was produced with intrauterine bacterial inoculation. The initial response to repeated inoculations of Escherichia coli was marked inflammatory response in the ut...

Chernel, S. v., 1918: Das vorkommen des Alpenfluhvogels (Accentor collaris Scop.) in Komitate Zala. Aquila Budapest, 24 114-121

Fraser, F.C., 1944: New Ethiopian and Oriental dragonflies (Order Odonata). Proceedings of the Royal Entomological Society of London (B): 13: 85-88

Fernandez Lastra, C.; Mariño, E.L.; Dominguez-Gil, A., 1987: Phosphomycin levels in serum and interstitial tissue fluid in a multiple dosage regimen in rabbits. The evolution of phosphomycin (Fosfocina), levels in serum and experimentally induced interstitial tissue fluid and the access of the drug to different organs were studied in rabbits after the administration of a single dose of 60 mg/kg and during...

Peter, S.J.; Miller, M.J.; Yasko, A.W.; Yaszemski, M.J.; Mikos, A.G., 1998: Polymer concepts in tissue engineering. Traumatic injuries, cancer treatment, and congenital abnormalities are often associated with abnormal bone shape or segmental bone loss. Restoration of normal structure and function in these cases requires replacement of the missing bone that may...

Bowers, M.J.; Orr, N.J.; Dempsey, S.; Alexander, H.Denis., 2006: Molecular genetics and transfusion management in a child with Bernard Soulier syndrome. We present a case of Bernard Soulier syndrome in a 9-year-old boy caused by a novel genetic mutation. This child was shown to be homozygous for a single nucleotide deletion (c.1077deIG) in the GP1BA gene not previously reported. Clinically, the bo...

Peltzer, Da, 1999: Measuring plant neighbour effects in different systems. Functional ecology 13(2): 283-287

Sethunathan, N.; Yoshida, T., 1973: Parathion degradation in submerged rice soils in the Philippines. The persistence of parathion in four Philippine rice soils was investigated in submerged and upland conditions. The parathion in the soils after incubation at 30 deg C was extracted with a hexane-acetone mixture and the amount was determined by ga...

Ozden, S.; Poirier, B., 1985: Dengue virus induced polypeptide synthesis. Brief report. Dengue 2 virus polypeptide synthesis was investigated in BHK21 cells. Nine or ten virus induced polypeptides were identified, three of which are glycoproteins as demonstrated by tunicamycin treatment of infected cells. We performed pulse chase exp...