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Associations between timing of exposure to ultraviolet radiation, T-stage and survival in prostate cancer


, : Associations between timing of exposure to ultraviolet radiation, T-stage and survival in prostate cancer. Cancer Detection and Prevention 31(6): 443-449

Background: Exposure to ultraviolet radiation (UVR) has been inversely associated with prostate cancer risk. We determined if skin type and UVR exposure are linked with parameters of prostate cancer outcome. Methods: We used a questionnaire to determine UVR exposure parameters and skin type in 553 men with prostate cancer and, using logistic regression and survival analysis, studied their association with T-stage, Gleason score, and survival after starting hormone manipulation therapy. Results: UVR exposures 10, 20, and 30 years before diagnosis were inversely associated with T-stage. The odds ratio (OR) for UVR exposure 10 years before diagnosis was lowest (OR = 0.69, 95% CI = 0.56-0.86). ORs were lower in men with skin types I/II than III/IV. Skin types I/II were associated with longer survival after commencing hormone therapy (hazard ratio = 0.62, 95% CI = 0.40-0.95). Conclusions: Our finding that UVR exposure is beneficial is compatible with accumulating data showing sunlight has a protective effect on disease phenotype.

US$19.90

PMID: 18061372

DOI: 10.1016/j.cdp.2007.10.017


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