+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones

, : Effect of ezetimibe on the prevention and dissolution of cholesterol gallstones. Gastroenterology 134(7): 2101-2110

Background & Aims: cholesterol cholelithiasis is one of the most prevalent and most costly digestive diseases in developed countries and its incidence has increased markedly in Asian countries owing to the adoption of Western-type dietary habits. Because animal experiments showed that high efficiency of intestinal cholesterol absorption contributes to gallstone formation, we explored whether the potent cholesterol absorption inhibitor ezetimibe could prevent gallstones and promote gallstone dissolution in mice and reduce biliary cholesterol content in human beings. Methods: Male gallstone-susceptible C57L mice were fed a lithogenic diet and concomitantly administered with ezedmibe at 0, 0.8, 4, or 8 mg/kg/day for 8 or 12 weeks. Gallbladder biles and gallstones were examined by microscopy. Gallbladder emptying in response to cholecystokinin octapeptide was measured gravimetrically. Biliary lipid outputs were analyzed by physical-chemical methods. Cholesterol absorption efficiency was determined by fecal dual-isotope ratio and mass balance methods. Lipid changes in gallbladder biles of gallstone patients vs overweight subjects without gallstones were examined before (clay 0) and at 30 days after ezetimibe treatment (20 mg/day). Results: Ezetimibe prevented gallstones by effectively reducing intestinal cholesterol absorption and biliary cholesterol secretion, and protected gallbladder motility function by desaturating bile in mice. Treatment with ezedmibe promoted the dissolution of gallstones by forming an abundance of unsaturated micelles. Furthermore, ezetimibe significantly reduced biliary cholesterol saturation and retarded cholesterol crystallization in biles of patients with gallstones. Conclusions: Ezetimibe is a novel approach to reduce biliary cholesterol content and a promising strategy for preventing or treating cholesterol gallstones by inhibiting intestinal cholesterol absorption.


PMID: 18442485

DOI: 10.1053/j.gastro.2008.03.011

Other references

Kordowiak, A.; Kaczmarski, F., 1980: Short-term action of streptozotocin on biochemical activity and morphology of the rat liver golgi apparatus. After six hours, the diabetogenic dose of streptozotocin has neither induced the release of hepatocyte cytoplasmic enzyme nor visibly injured the hepatocyte. As a rule, however, these doses of streptozotocin induced various responses in individual...

Lorenz v Liburnnn, Ludwig., 1908: Vorlage des rekonstruierten Skeleltes eines fossilen Riesenhalbaffen aus Madagaskar. Verhandlungen der Zoologisch-Botanischen Gesellschaft in Wien, 58 (34-35)

Pleticha, P., 1968: Das relative Wachstum der Zauneidechse (Lacerta agilis L.). Zoologicke Listy, 17: 63-74

Tyrrell, D.A., 1967: Clinical syndromes with mycoplasma infections. Postgraduate Medical Journal 43: Suppl 43:104-6

Reinsch, N.; Thomsen, H.; Xu, N.; Brink, M.; Looft, C.; Kalm, E.; Brockmann, G.A.; Grupe, S.; Kühn, C.; Schwerin, M.; Leyhe, B.; Hiendleder, S.; Erhardt, G.; Medjugorac, I.; Russ, I.; Förster, M.; Reents, R.; Averdunk, G., 1999: A QTL for the degree of spotting in cattle shows synteny with the KIT locus on chromosome 6. The proportion of unpigmented coat on the trunk was determined from photographs of 38 German Simmental and 627 German Holstein bulls distributed over three generations. All 665 animals were members of 18 Holstein and 3 Simmental half-sib families....

Dimassi Theriou, K., 1998: Effects of exogenous ethylene, CO2 and GA3 on shoot proliferation in vitro of sweet cherry (Prunus avium L.). In in vitro experiments on shoot cultures of sweet cherry cv. Tragana Edessis, exposure to ethylene (0.01-10 micro l/litre) or GA3 (0-10 mg/litre) caused a marked increase in the percentage bud break and in shoot length, while CO2 (200-1200 micro...

O'Connell, D.L.; Heller, R.F.; Roberts, D.C.; Allen, J.R.; Knapp, J.C.; Steele, P.L.; Silove, D., 1988: Twin study of genetic and environmental effects on lipid levels. A study of 106 pairs of monozygotic (MZ) and 94 pairs of dizygotic (DZ) twins tested the hypothesis that part of the previously described genetic influence on blood lipid levels can be ascribed to closer similarities among MZ than among DZ twin pa...

Yang, J-Cun.; Sun, Y.; Xu, C-Xiang.; Dang, Q-Li.; Li, L.; Xu, Y-Gang.; Song, Y-Jun.; Yan, H., 2014: Correlation between red blood cell transfusion volume and mortality in patients with massive blood transfusion: A large multicenter retrospective study. This study aimed to explore the correlation between red blood cell (RBC) transfusion volume and patient mortality in massive blood transfusion. A multicenter retrospective study was carried out on 1,601 surgical inpatients who received massive blo...

Royzenman F.M., 1997: Quantitative prognostic evaluation criteria of graphite deposits. Graphite deposits of Aldan and Karelia are cited as cases in point to illustrate the possibility of quantitative prognostic evaluation of graphite-bearing areas providing for the determination of main economic parameters, i.e., sizes of graphite-b...

Malle, E.; Marsche, G.; Panzenboeck, U.; Sattler, W., 2005: Myeloperoxidase-mediated oxidation of high-density lipoproteins: fingerprints of newly recognized potential proatherogenic lipoproteins. Substantial evidence supports the notion that oxidative processes participate in the pathogenesis of atherosclerotic heart disease. Major evidence for myeloperoxidase (MPO) as enzymatic catalyst for oxidative modification of lipoproteins in the ar...