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Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds

, : Notch regulation of progenitor cell behavior in quiescent and regenerating auditory epithelium of mature birds. Developmental Biology 326(1): 86-100

Unlike mammals, birds regenerate auditory hair cells (HCs) after injury. During regeneration, mature non-sensory supporting cells (SCs) leave quiescence and convert into HCs, through non-mitotic or mitotic mechanisms. During embryogenesis, Notch ligands from nascent HCs exert lateral inhibition, restricting HC production.


PMID: 19013445

DOI: 10.1016/j.ydbio.2008.10.033

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