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Role of platelet-derived growth factors in physiology and medicine


, : Role of platelet-derived growth factors in physiology and medicine. Genes & Development 22(10): 1276-1312

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) have served as prototypes for growth factor and receptor tyrosine kinase function for more than 25 years. Studies of PDGFs and PDGFRs in animal development have revealed roles for PDGFR-alpha signaling in gastrulation and in the development of the cranial and cardiac neural crest, gonads, lung, intestine, skin, CNS, and skeleton. Similarly, roles for PDGFR-alpha signaling have been established in blood vessel formation and early hematopoiesis. PDGF signaling is implicated in a range of diseases. Autocrine activation of PDGF signaling pathways is involved in certain gliomas, sarcomas, and leukemias. Paracrine PDGF signaling is commonly observed in epithelial cancers, where it triggers stromal recruitment and may be involved in epithelial-mesenchymal transition, thereby affecting tumor growth, angiogenesis, invasion, and metastasis. PDGFs drive pathological mesenchymal responses in vascular disorders such as atherosclerosis, restenosis, pulmonary hypertension, and retinal diseases, as well as in fibrotic diseases, including pulmonary fibrosis, liver cirrhosis, scleroderma, glomerulosclerosis, and cardiac fibrosis. We review basic aspects of the PDGF ligands and receptors, their developmental and pathological functions, principles of their pharmacological inhibition, and results using PDGF pathway-inhibitory or stimulatory drugs in preclinical and clinical contexts.

US$19.90

PMID: 18483217

DOI: 10.1101/gad.1653708


Other references

Kunchithapatham J., 1970: Inter varietal crosses in datura fastuosa d. Indian Science Congress Association Proceedings 57(4): 290

Gráda, C.Ó., 1975: A note on nineteenth-century Irish emigration statistics. Summary On the basis of a re-examination of the different statistical series of post-Famine Irish emigration, this paper finds (1) that the total outflow was larger than the figures for total emigration allow, and (2) that permanent movement to Gr...

McCaulou Douglas R.; Huling Scott G., 1999: Compatibility of bentonite and DNAPLs. The compatibility of dense nonaqueous phase liquids (DNAPLs), trichloroethylene (TCE), methylene chloride (MC), and creosote with commercially available sodium bentonite pellets was evaluated using stainless steel, double ring, falling head permea...

Egger, K.; Werner, M.; Meining, A.; Ott, R.; Allescher, H-D.; Höfler, H.; Classen, M.; Rösch, T., 2002: Biopsy surveillance is still necessary in patients with Barrett's oesophagus despite new endoscopic imaging techniques. Endoscopic surveillance including stepwise four quadrant biopsies (4QB) is still regarded as the standard approach in patients with Barrett's oesophagus (BO). Several methods such as dye staining with methylene blue (MB) and tissue autofluore...

Xu, S.; Wang, P.; Dong, Y., 2016: Measuring Electrolyte Impedance and Noise Simultaneously by Triangular Waveform Voltage and Principal Component Analysis. In order to measure the impedance variation process in electrolyte solutions, a method of triangular waveform voltage excitation is investigated together with principal component analysis (PCA). Using triangular waveform voltage as the excitation...

Sugawara, Takashi, 1996: A new species of Asarum (Aristolochiaceae) from Goto Islands, Japan. Asarum mitoanum, a new species of Asarum from Goto Isls., the northwestern Kyushu District of Japan, is described and illustrated. This species is related to Asarum hexalobum (sect. Aschidasarum), especially to var. controversum in sharing the cal...

Anonymous, 2012: Gossan characterization in the Quaraí and Los Catalanes amethyst geode districts Brazil and Uruguay, Parana volcanic province, using rock geochemistry and gamma-spectrometry. We report the discovery of a large number (probably thousands) of gossans in the intraplate Paran volcanic province in South America, based on observations from satellite images and field work supplemented with rock geochemistry and geophysics. We...

Halliday, R.B., 2003: Taxonomic imperatives in stored product acarology. Despite decades of study, there are still many unresolved problems in the study of mite pests of stored food, caused by an inadequate level of research in taxonomy and basic biology. There have been several recent examples of these problems from A...

Anderson, W.F., 1974: Isolation and translation of messenger RNA from beta-thalassemia red cells. Annals of the New York Academy of Sciences 232(0): 15-32

Zope, L.C., 1940: The growth effects of thiamin chloride, ascorbic acid and phytohormones on belladonna and ricinus. The germination and growth of Atropa belladonna and Ricinus communis were affected when their seeds were subjected to dust treatment with phytohormones used alone or in combination with vitamins B1 and C. The combined effect was greater than the s...