+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells

, : Wingless signaling directly regulates cyclin E expression in proliferating embryonic PNS precursor cells. Mechanisms of Development 125(9-10): 857-864

Cell proliferation and cell type specification are coordinately regulated during normal development. Cyclin E, a key G1/S cell cycle regulator, is regulated by multiple tissue-specific enhancers resulting in dynamic expression during Drosophila development. Here, we further characterized the enhancer that regulates cyclin E expression in the developing peripheral nervous system (PNS) and show that multiple sequence elements are required for the full cyclin E PNS enhancer activity. We further show that Wg signaling is important for the expression of cyclin E in the sensory organ precursor (SOP) cells through two conserved TCF binding sites. Blocking Wg signaling does not completely block SOP cell formation but does completely block SOP cell proliferation as well as the subsequent differentiation.


PMID: 18606221

DOI: 10.1016/j.mod.2008.06.006

Other references

He, B.; Tao, H.; Liu, S.; Wei, A., 2015: Protective effect of carboxymethylated chitosan on hydrogen peroxide-induced apoptosis in nucleus pulposus cells. Although the etiology of intervertebral disc degeneration is poorly understood, one approach to prevent this process may be to inhibit apoptosis. In the current study, the anti‑apoptotic effects of carboxymethylated chitosan (CMCS) in nucleus pu...

Heo, N.; Seff, K., 1988: Cesium vapor reacts with K+-exchanged zeolite A to give fully Cs+-exchanged zeolite A containing (Cs4)3+ clusters. ACS Symposium series American Chemical Society68(368): 177-193

Delegue, L., 1961: Neonatal emergency anesthesia. Anesthesie, Analgesie, Reanimation 18: 517-525

Anasiewicz, A., 1986: Insects pollinating flowers of celery parsley and fennel ii. hymenoptera with special reference to the superfamily apoidae. Investigations conducted in 1977-1981 indicated that Hymenoptera are of great importance for seed production of celery, parsley, and fennel, giving way only to hover flies (Diptera, Syrphidae). Among them the Hymenoptera bees (Apoidea) belonging t...

Lehrhaupt, N.B., 2002: Alveolar distraction: a possible new alternative to bone grafting. Distraction osteogenesis is a new concept to periodontics that may replace the more traditional bone grafting techniques of onlay grafts and titanium membrane procedures. Distraction osteogenesis is not fraught with the complications of graft and...

Hobday, J.D., 1972: The incidence of pollen sensitivities on skin test and bronchial challenge in asthmatic children in Perth, Western Australia. Medical Journal of Australia 1(4): 161-164

Ukwatta, E.; Yuan, J.; Rajchl, M.; Qiu, W.; Tessier, D.; Fenster, A., 2014: 3-D carotid multi-region MRI segmentation by globally optimal evolution of coupled surfaces. In this paper, we propose a novel global optimization based 3-D multi-region segmentation algorithm for T1-weighted black-blood carotid magnetic resonance (MR) images. The proposed algorithm partitions a 3-D carotid MR image into three regions: wa...

Jhala, A.J.; Gao, S.; Gerik, J.S.; Qin, R.; Hanson, B.D., 2012: Effects of surface treatments and application shanks on nematode, pathogen and weed control with 1,3-dichloropropene. Preplant fumigation with methyl bromide (MeBr) has been used for control of soilborne pests in high-value annual, perennial and nursery crops, but is being phased out. In 2007 and 2008, research trials were conducted to evaluate the effects of sur...

Cammarota, C.; Curione, M., 2008: Analysis of extrema of heartbeat time series in exercise test. The heartbeat time series of the electrocardiogram recorded during exercise test clearly reflects the physiological control mechanism of the autonomic nervous system on heart rate. This series shows both decreasing and increasing trends and variab...

Arakelov, GG., 1972: Relationships between synaptic and pacemaker potentials of giant neurons of the snail Helix pomatla. Zhurnal evol Biokhim Fiziol, 84: 404-413