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Arterial wall potassium in renal hypertensive rats

, : Arterial wall potassium in renal hypertensive rats. Circulation Research 7(2): 219-223

The K concentration of the aorta of the rat parallels the level of blood pressure, the Na concentration remaining essentially the same. Thus, the aortas of renal hypertensive rats have a K content well above normal. Reduction of blood pressure through K deprivation causes a depression of blood pressure and return of aorta K content to normal values. The administration of cortisone to such rats restores the blood pressure to hypertensive levels and a concomitant increase in K content of the aorta, but not in blood, myocardium or skeletal muscle. It is suggested that under the above conditions the K of the artery wall regulates tone which is reflected in blood pressure changes.


PMID: 13629820

DOI: 10.1161/01.RES.7.2.219

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