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Beitrage zur Chemie des menschlichen Magensaftes


, : Beitrage zur Chemie des menschlichen Magensaftes. Wien Arch Inn Med 19(3): 413-450

Normal gastric juice during active secretion contains (mean values) 8.9 mgm. % Ca, 29.6 of K, 1.77 of Mg, and 221.8 of Na. The highest observed values were Ca 23.4 mgm. %, K 88.9 mgm. %, Mg 3.7 mgm. %, and Na 552 mgm. %. The lowest values observed were Ca 2.2 mgm. %, K 3.1 mgm. %, Mg 3 mgm. %, and Na 9 mgm.%. There appeared to be no relationship between degree of acidity and the concentration of the 4 ions, Ca, K, Mg, and Na. The sum of the quotients of the concentration numbers of the cations divided by their atomic weights about equals the total chloride divided by its atomic weight. The K/Ca quotient was 3.8. The neutral Cl/Na quotient was 1.4. Gastric juice of the early morning differed in composition from that later in the day. The gastric juice obtained from the lower part of the stomach was more constant in its composition than that obtained from the upper part. The filtrate and centrifugate contained more Na than the whole juice, but less of the other 3 ions. Adrenalin first decreased, then increased, secretion. Acidity increased after adrenalin administration, then decreased. Cl concentration rose. The concentration of the 4 cations decreased, that of Na decreasing most. Atropine had a 2-phasic action, first increasing acidity and secretion, then lowering it. Ergo-tamine produced a marked decrease in HC1, a slight decrease in the total Cl. There was an increase in neutral chloride, paralleled by increase in K and Na. Physo-stigmine produced an increase in total secreted gastric juice, but a decrease in acidity. The metallic cations were unchanged in concentration, except K, which decreased slightly. Physostigmine antagonized the gastric action of adrenalin. Intravenous injection of insulin produced a hypoglycemic condition, associated with rise in total secretion and acidity of the gastric juice, followed by a decrease. Cl, K, and Mg increased. Epithelial bodies produced no regular effect on acidity and secretion, but often increased the latter somewhat. Ca never increased; K, Na and Mg frequently did. Intravenous injection of 50 cc. NaHCO3 produced a sudden decided decrease of acidity, then an increase followed by a second decrease. Na and K decreased and to a smaller extent Mg and Ca. In general, in alkalization, K increases and C decreases. Histamine produced a strong increase in Cl and H and a somewhat smaller increase in the metallic cations. There was a negative Cl wave at the beginning of digestion, associated with changes in concentration of the metallic ions.

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