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Biochemical changes in exposure and acclimation to cold environments

, : Biochemical changes in exposure and acclimation to cold environments. British Medical Bulletin 17: 25-31

Maintenance of homoeothermy in animals exposed to cold is a special case in the general problem of regulation of cell metabolism. Thermo regulation either in the warm-acclimated or in the cold-acclimated rat can be a useful tool for the study of regulatory processes associated with increased energy release. However, understanding of the intimate mechanisms involved is dependent on advances in identification of the key factors limiting metabolism in various tissues. The striking shift from shivering to non-shivering thermogenesis in the cold-acclimated rat, and the importance of noradrenaline as mediator of the effect, are the most interesting facts recently acquired in the study of acclimation. Further advances await elucidation of the mechanisms involved in the suppression of shivering, direct identification of the tissues involved in non-shivering thermogenesis, and elucidation of the mechanism of action of thermogenic hormones at the mitochondrial level.


PMID: 13721994

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