+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Biochemical changes in extracorporeal circulation

, : Biochemical changes in extracorporeal circulation. Sbornik Ved Praci 2(5): 747-765

Changes in oxygen supply inthe tissues during extracorporeal circulation were studied in 37 dogs. Duration of the perfusion 30 min. In the basic series the authors applied minute volume of 50 ml/kg/min. During the experiment reduction of oxygen in the tissues, increase in the arteriovenous difference in bloodoxygen, decrease in the alkali reserve and reduction of pH can be observed. In the authors' opinion acidosis is based on the increase in anions which comes about in anaerobic oxydation of carbohydrates due to insufficient supply of oxygen to the tissues. In the course of extra-corporeal circulation centralization of the circulation occurs which deteriorates the condition. Infusion of noradrenalin has a favourable influence on the return of venous blood by regulating the pressure conditions. It does not, however, influence favourably the composition of body fluids; on the contrary, by deepening the centralization of the circulation it makes the oxygen supply to the periphery still worse and reduces thus the percentage of survival in the experimental animals. An increase in the minute volume to 70 ml/min/kg and a blockade by ganglio-plegics (Pendiomid) improves essentially the oxygen supply to the tissues, reduces acidosis as well as the other manifestations of anaerobic metabolism of carbohydrates bringing about acidosis, and increases essentially the percentage of survival in the experimental animals. The question of principle of acidosis occurring in the course of extracorporeal circulation is discussed as well as the action of noradrenalin and the effect of increased minute volume with a simultaneous block by ganglio-plegics.


Other references

Magaud, J.P.; Brochier, J.; Rimokh, R.; Germain, D., 1984: Chromosomal R-banding with an anti-native DNA (dG-dC specificity) monoclonal antibody. Chromosomal R-banding was obtained by the use of an anti ds-DNA monoclonal antibody, specific for dG-dC, at an appropriate dilution. Better results were observed when chromosome preparations were trypsinized for 10 sec. with 0.02% trypsin solution...

Peretz, M.; Weiner, L.M.; Burstein, Y., 1997: Cysteine reactivity in Thermoanaerobacter brockii alcohol dehydrogenase. The free cysteine residues in the extremely thermophilic Thermoanaerobacter brockii alcohol dehydrogenase (TBADH) were characterized using selective chemical modification with the stable nitroxyl biradical bis(1-oxy-2,2,5,5-tetramethyl-3-imidazoli...

Anonymous, 2016: Correction: Drugs in breastfeeding. [This corrects the article DOI: 10.18773/austprescr.2015.056.].

Ulyanova, Y.V.; Blackwell, A.E.; Minteer, S.D., 2006: Poly(methylene green) employed as molecularly imprinted polymer matrix for electrochemical sensing. This paper describes the development of a molecularly imprinted polymer (MIP) for theophylline that can be used for electrochemical sensing. Theophylline is a commonly used medication for the treatment of asthma. Due to its very narrow therapeutic...

Chuang, C.-Lin; Chen, K.-Po; Kwan, S.-Yeong; Yang, W.-Chang, 2004: Creutzfeldt-Jakob-like EEG in a patient with end-stage renal failure. Nephrology Dialysis Transplantation 19(1): 252-254

Flint, Harrison L,, 1986: Elms of yesterday and today: the search continues for a replacement (and cure) for the American elm. Horticulture 64: 7

Koryagin, A., 1983: On the agenda. Lancet 1(8319): 281-281

Schack Nielsen, L.; Holst, C.; Sorensen, T.I.A., 2001: Blood pressure in relation to birth weight and weight history during childhood and adulthood in Danish men. International Journal of Obesity 25(Supplement 2): S76, May

Picken, L.E.R., 1936: The mechanism of urine formation in Invertebrates. I. The excretion mechanism in certain Arthropods. Journal of exp Ecol Cambridge, 13: 309-328

Ferraz, A.; Zhang, J.; Sebastião, P.J.; Ribeiro, A.C.; Dong, R.Y., 2014: Proton and deuterium nuclear spin relaxation study of the SmA and SmC* phases of BP8Cl-d17 : a self-consistent analysis. A self-consistent analysis of proton and deuterium nuclear spin relaxation times in the smectic phases of a partially deuterated smectogen is presented here. Proton spin-lattice relaxation times T(1Z) were measured as a function of Larmor frequenc...