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Central cholinergic blockade of the conditioned avoidance response in rats


, : Central cholinergic blockade of the conditioned avoidance response in rats. Psychopharmacologia 6(1): 31-41

The effects of arecoline, Tremorine and chlorpromazine were studied in rats conditioned in shuttlebox avoidance and lever-press avoidance procedures. Conditioned avoidance response (CAR) blockade produced by subtremor doses of arecoline and Tremorine was felt to result from central cholinergic stimulation since the effects of both drugs were prevented by the tertiary anticholinergic, atropine, but not by the quaternary agent, methantheline. In both avoidance procedures the observed CAR blockade produced by these cholinergics suggested not reduction in fear or anxiety drive, popularly ascribed to chlorpromazine, but rather heightened anxiety and indecision about appropriate performance for avoiding the impending danger of shock. The behavioral pattern of the trained animals under the influence of these cholinergic drugs was, in fact, remarkably similar to behavior of the unconditioned rats during the earlier stages of avoidance training. The possible implications of these findings are discussed.

US$19.90

PMID: 4378511

DOI: 10.1007/bf00710912


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