+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Central cholinergic blockade of the conditioned avoidance response in rats

, : Central cholinergic blockade of the conditioned avoidance response in rats. Psychopharmacologia 6(1): 31-41

The effects of arecoline, Tremorine and chlorpromazine were studied in rats conditioned in shuttlebox avoidance and lever-press avoidance procedures. Conditioned avoidance response (CAR) blockade produced by subtremor doses of arecoline and Tremorine was felt to result from central cholinergic stimulation since the effects of both drugs were prevented by the tertiary anticholinergic, atropine, but not by the quaternary agent, methantheline. In both avoidance procedures the observed CAR blockade produced by these cholinergics suggested not reduction in fear or anxiety drive, popularly ascribed to chlorpromazine, but rather heightened anxiety and indecision about appropriate performance for avoiding the impending danger of shock. The behavioral pattern of the trained animals under the influence of these cholinergic drugs was, in fact, remarkably similar to behavior of the unconditioned rats during the earlier stages of avoidance training. The possible implications of these findings are discussed.


PMID: 4378511

DOI: 10.1007/bf00710912

Other references

Husain, A., 1986: Economy revolves around cotton. Cotton International edition: 82-184

Unzeitig, V.; Mardesic, T., 1995: On the concept of gynecology and obstetrics as a profession. Ceska Gynekologie 60(1): 45-45

Jahoor, A.; Ghamande, S.; Jones, S.; Boethel, C.; White, H.D., 2017: Mediastinitis Following Endobronchial Ultrasound-guided Transbronchial Needle Aspiration. Mediastinitis is a rare complication of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Recent reports of infectious complications following EBUS-TBNA involved oropharyngeal bacteria. Here, we report 2 unusual cases o...

Wolfaardt, J.F.; Cleaton-Jones, P.; Fatti, P., 1986: The occurrence of porosity in a heat-cured poly (methyl methacrylate) denture base resin. Journal of Prosthetic Dentistry 55(3): 393-400

Anonymous, 1971: Puff of smoke. British Medical Journal 4(5779): 67-68

Secil, Y.; Ozdedeli, K.; Altay, B.; Aydogdu, I.; Ertekin, C., 2003: Genital sympathetic skin responses in female sexual dysfunction. Journal of Urology 169(4 Supplement): 97, April

Krane R.J.; Siroky M.B., 1991: Clinical neuro urology second edition. This newly, revised, second edition provides essential information on neurologic disorders and diseases of the genito-urinary tract, and advances in the field of neuro-urology including pharmacotherapy and surgical procedures. Six sections divide...

Mellon, J.E.; Cotty, P.J., 1996: Effects of seed storage proteins on aflatoxin production by Aspergillus flavus. Plant Physiology (Rockville) 111(2 SUPPL ): 87

Biber, J.; Forgo, J.; Murer, H., 1988: Modulation of Na+-Pi cotransport in opossum kidney cells by extracellular phosphate. The effect of the extracellular concentration of Pi on the Na+-dependent phosphate transport activity of OK cells was investigated. When incubated with extracellular Pi at concentrations of 200 microM or less, Na+-Pi cotransport increased approxim...

Maliyamkono, T.L.; Ishumi, A.G.M.; Wells, S.J., 1982: Higher education and development in Eastern Africa. A report of the Eastern African Universities Research Project on the impact of overseas training and development. The book represents the findings of the East African Universities Research Project on the impact of overseas training of East African personnel. The object of the study is a comparison of locally and overseas trained personnel to evaluate differen...