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Comparison of enterogastrone derived from various sections of the intestine

, : Comparison of enterogastrone derived from various sections of the intestine. Gastroenterology 43: 457-461

Extracts were prepared from all of the different parts of the intestines of hogs and dogs to determine what quantities of enterogastrone extracts may be obtained from successive 50- to 100-cm pieces of intestine and what differences there were in their influence on gastric secretion. The extracts were injected intravenously in 50-mg doses into dogs with Heidenhain pouches. The secretion was maintained at 50 % of the maximum by injecting suitable doses of histamine. The largest amounts of extracts were obtained from the proximal parts of the small and initial section of the large intestine in hogs as well as dogs. The strongest inhibitory action in the first hour after injection was exerted by enterogastrone derived from the initial parts of the small intestine, in extracts from both dogs and hogs. The extracts of the terminal ileum and of the large intestine of both species also evoked a strong inhibitory influence, mostly in the second hour after injection. Enterogastrone extracts derived from dogs exerted a stronger activity than hog enterogastrone. The extracts from the middle section of the small intestine did not inhibit and in some instances stimulated.


PMID: 14031422

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