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Concentrated human albumin in the treatment of shock

, : Concentrated human albumin in the treatment of shock. Archives of Internal Medicine 77: 564-575

Human albumin was given to 7 normal subjects and to 33 patients with circulatory failure. There were no unfavorable reactions. In the normal subjects, a rise in right atrial pressure and a fall in the hematocrit reading always occurred. The changes in cardiac output were variable. The arterial pressure and pulse rate usually remained unchanged. In patients with hemorrhage, chest wounds, pericardial tam-ponade, burns, dehydration and infection, satisfactory hemo-dilution occurred when albumin was given in concentrated form (25% soln.). The avg. increase in vol. of blood for the entire group/g. of albumin administered was 14.0 ml. Dehydration was present in 4 of these patients, and the avg. increase/g. of albumin was 13.0 ml. Eleven patients received 50 g. of albumin in 15 mins. or less. The fact that these large quantities of protein can be given so rapidly makes concentrated albumin soln. a valuable material to have on hand in the accident ward. Human albumin is a useful substitute for plasma. It cannot replace the use of whole blood, but its small bulk, the ease and rapidity of its admn., its stability at room temp. and the absence of unfavorable reactions make it useful in many emergencies.


PMID: 20985849

DOI: 10.1001/archinte.1946.00210400089007

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