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Conversion of cholesterol to corticosteroids in adrenal homogenates

, : Conversion of cholesterol to corticosteroids in adrenal homogenates. Biochimica et Biophysica Acta 17(1): 136-137

It is concluded that homogenates of adrenal glands incubated as described are capable of converting cholesterol to corticosteroids, at least part of the side chain being oxidized to CO2. When similar experiments were carried out with carboxyl-labeled C14 acetate in the medium instead of labeled cholesterol, no radioactivity could be detected on the chromatograms or in the cholesterol isolated from the medium. Presence of ACTH in the medium did not affect any metabolic pathways investigated.


PMID: 13239637

DOI: 10.1016/0006-3002(55)90328-0

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