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DNA synthesis in irradiated intestinal epithelium

, : DNA synthesis in irradiated intestinal epithelium. Experimental Cell Research 19: 343-360

DNA (deoxyribonucleic acid) synthesis in the intestinal epithelium of X-irradiated mice was studied by means of autoradiography following labeling with tritiated thymidine. Radiation doses and time intervals between labeling and irradiation and sacrifice were varied widely. Irradiation results in a reduction of thymidine incorporation, the early phase of which is thought to be due to a block of DNA synthesis in cells irradiated while in the DNA synthesis phase. Of these cells, some subsequently die, the majority mature precociously, and some remain proliferative. DNA synthesis is resumed before cell division; in heavily irradiated animals, the surviving proliferative cells go through one or two cycles of DNA synthesis not followed by cell division. The migration of mature cells is not markedly affected by irradiation. The findings reported here, together with the results of previous studies, suggest that the transition of cells from the proliferative zone to the zone occupied by functional cells is subject to a control mechanism which is somehow associated with DNA synthesis.


PMID: 14445881

DOI: 10.1016/0014-4827(60)90013-6

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