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Derivatives Of (-)-Trans-2,3-Epoxysuccinic Acid And Some Of Their Biological Effects

, : Derivatives Of (-)-Trans-2,3-Epoxysuccinic Acid And Some Of Their Biological Effects. Journal of Medicinal Chemistry 6: 233-237

Symmetrical esters and amides as well as the nitrile have been prepared from the mold metabolite, (-)-trans-2,3-epoxysuccinic acid. Opening of the oxirane ring in epoxysuccinic acid and its methyl ester with ammonia and amines to form erythro-[beta]-hydroxy-L-aspartic acid and N-substituted analogs is discussed and some products are described.


PMID: 14185974

DOI: 10.1021/jm00339a004

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