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Effect Of Hypervolemia On Ratio Of Pulmonary To Systemic Vascular Volume

, : Effect Of Hypervolemia On Ratio Of Pulmonary To Systemic Vascular Volume. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 114: 208-210

The volume of blood in the lungs and the left side of the heart (L LHV) and the total blood volume were determined for 15 anesthetized dogs. The LLHV averaged 12 ml/kilogram of body weight or 12.5% of the total blood volume. Infusion of fresh blood or of dextran, 6%, produced hypervolemia sufficient to increase the total blood volume by an average of 46%. During the hypervolemia, the proportion of LLHV to the total volume was essentially unchanged. This was also true for 3 conscious dogs. Thus there was no evidence from these observations of a specific reservoir function of the lungs. In experiments on 4 conscious dogs, the LLHV was measured at rest and during exercise at different degrees of hypervolemia. Regardless of the initial LLHV there was little change from this initial value as the cardiac output increased up to threefold with exercise.


PMID: 14076883

DOI: 10.3181/00379727-114-28627

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