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Effect of some preparations of adrenocorticotrophic hormone on the colour of Bufo arenarum Hensel

, : Effect of some preparations of adrenocorticotrophic hormone on the colour of Bufo arenarum Hensel. Journal of Endocrinology 11(1): 50-56

A comparative study of the action of intermedin and adrenotropic hormone on the color of the skin and on the adrenals of the toad Bufo arenarum was carried out. Intermedin and ACTH darken the skin of the pale hypo-physectomized toad but comparatively, intermedin is far more active than ACTH. Both preparations are more active than those of the pressor and oxytocic posterior pituitary principles. The melanotropic action of ACTH does not depend on the presence of the adrenals or the sex of the toad. Treatment with formaldehyde or boiling with NaOH, which are known to destroy ACTH activity do not affect the action of ACTH on the skin; the latter treatment may even increase it. Unlike ACTH, intermedin does not prevent atrophy of the adrenals after hypophysectomy or the development of asthenia. It is concluded, that the adrenotropic and chromatophorotropic actions of the hypophysis are produced by 2 different substances.


PMID: 13184080

DOI: 10.1677/joe.0.0110050

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