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Effects of physiological purines on the development of the chick embryo


, : Effects of physiological purines on the development of the chick embryo. Biochemical Pharmacology 7: 154-158

The commonly occurring purine bases, ribo-nucleosides and deoxyribonucleosides were injected into the yolk sac of the 4-day-old chick embryo to determine their toxicity and teratogenic activity. The deoxyribonucleosides were most toxic, with dGuR, dAdR and dHxR having estimated LD50's of 2, 4 and 4 to 8 /moles/egg, respectively. The deoxyribosyl derivatives caused marked disturbances in development of the 4-day embryo, with stunting of growth, edema, facial defects, absent bones and shortened extremities. dGuR was most active in producing weight inhibition and severe developmental disturbances; these effects were seen at 1 /mole/egg for dGuR, in contrast to 16 umoles/egg for dHxR, and at an excess of 8 umoles/egg for dAdR.

US$19.90

PMID: 13751540

DOI: 10.1016/0006-2952(61)90152-6


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