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Electrocardiographic changes and concentration of calcium in serum following intravenous injection of calcium chloride


, : Electrocardiographic changes and concentration of calcium in serum following intravenous injection of calcium chloride. Amer Jour Physiol 125(1): 162-171

Dilute solns. of CaCl2 were injected intraven. into dogs at a uniform rate so that the cone, of Ca in the serum rose gradually and continuously. Frequent electrocardiograms were taken and detns. of Ca cone, in the serum were made at intervals until death; these were then compared. A sequence of electrocardiographic changes appeared as follows: First slowing phase; frequently associated with T wave changes and changes in the A-V conduction; apparent at Ca cones, ranging from 15 to 65 mgm. Rapid phase; increased automaticity frequently ending in ventricular fibrillation; apparent at Ca cones, from 25 to 90 mgm.%. Second slowing phase; general depression ending in cardiac arrest without fibrillation; occurring only in animals surviving the rapid phase; apparent at Ca cones, of 70 to 190 mgm.%. Death during acute expts. may be caused either by sudden ventricular fibrillation or by cardiac arrest. Animals surviving the acute expt. may succumb later for some unassigned cause.

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