geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Exhaled nitric oxide, but not serum nitrite and nitrate, is a marker of interstitial lung disease in systemic sclerosis


, : Exhaled nitric oxide, but not serum nitrite and nitrate, is a marker of interstitial lung disease in systemic sclerosis. Nitric Oxide 20(3): 200-206

Nitric oxide metabolites (NOx) in serum, and alveolar concentration of NO (CANO), are markers of inflammation and alveolitis, respectively, in systemic sclerosis (SSc). We prospectively evaluated the usefulness of both NOx and CANO to assess lung involvement and skin fibrosis in SSc. Serum NOx, and CANO measured by two different methods, namely the two-compartment (2CM) and the “trumpet” models (TM), were concomitantly assessed in 65 patients with SSc and 17 healthy controls. Whilst serum NOx remained comparable between groups, CANO were significantly higher in SSc patients (n = 65, 6.7 ppb; 4.8–9.7 and 5.9 ppb; 3.9–8.9) as compared with controls (n = 17, 3.0 ppb; 2.0–3.8 and 1.8 ppb; 1.1–2.9, p < 0.001, p < 0.001) using the 2CM and the TM, respectively). CANO from SSc patients with interstitial lung disease (ILD) (n = 26, 8.6 ppb; 6.5–10.9 and 8.5 ppb; 5.9–10.7) or pulmonary arterial hypertension (n = 12, 7.3 ppb; 6.5–10.4 and 6.9 ppb; 5.4–9.9) were significantly higher as compared with patients without ILD (n = 27, 4.9 ppb; 3.8–6.5 and 4.7 ppb; 2.8–5.7; p < 0.001 and p < 0.001) using the 2CM and the TM, respectively). CANO assessed either by the 2CM or the trumpet model were directly related to the extent of ILD and inversely related to DLCO. There was no correlation between NOx and ILD, or DLCO. Neither CANO nor NOx was correlated with skin fibrosis and no relationship was found between CANO and NOx.Alveolar concentration of NO, but not serum NOx, closely correlates with the extent of ILD in patients with systemic sclerosis. Neither parameter, however, is related to skin fibrosis.

US$19.90

PMID: 19100854

DOI: 10.1016/j.niox.2008.11.004


Other references

Raynaud, A.; Kan, P.; Bouche, G.; Duprat, A.M., 1995: A slow worm embryo presenting supernumerary limb buds following treatment with a growth factor. Description of an embryo of the slow-worm (Anguis fragilis L.) displaying supernumerary anterior limb buds induced by a localized treatment with a fibroblastic growth factor (FGF-2).

Labayen, I.; Ruiz, J.R.; Ortega, F.B.; Huybrechts, I.; Rodríguez, G.; Jiménez-Pavón, D.; Roccaldo, R.; Nova, E.; Widhalm, K.; Kafatos, A.; Molnar, Dénés.; Androutsos, O.; Moreno, L.A., 2015: High fat diets are associated with higher abdominal adiposity regardless of physical activity in adolescents; the HELENA study. Failure to attain fat balance may contribute to obesity development even without excessive energy intake. The objective of this study was to examine the associations of dietary macronutrient distribution with abdominal adiposity in adolescents and...

Melo, G.Barreto.; Bispo, P.José.Martins.; Regatieri, C.Vinícius.Saito.; Yu, M.Cecília.Zorat.; Pignatari, Aônio.Carlos.Campos.; Höfling-Lima, A.Luisa., 2011: Incidence of endophthalmitis after cataract surgery (2002-2008) at a Brazilian university-hospital. To report on the incidence, diagnostic technique, and microbiological features of endophthalmitis at a university-setting in Brazil. All cases of presumed postoperative endophthalmitis from 2002 to 2008 at a teaching-hospital were included. Main d...

Wang, M.H.i; Chen, Y.Q.ng; Flad, H.D.eter; Baer, H.H.; Ulmer, W.F.ist And Artur J., 1993: Inhibition of interleukin-6 release and T-cell proliferation by synthetic mirror pseudo cord factor analogues in human peripheral blood mononuclear cells. The effects of synthetic alkyl ((alkyl 6-deoxy-a-D-gluco-heptopyranosyluronate) 6-deoxy-a-D-gluco-heptopyranoside) uronates, a novel type of mirror pseudo cord factor, on the in vitro modulation of interleukin-6 production and T-cell proliferation...

Uzun, N.; Gündüz, Aşegül.; Karadeniz, D.; Kiziltan, M.E., 2017: Circadian Change in Blink Reflex Recovery in Restless Legs Syndrome. Restless legs syndrome (RLS) is associated with dysfunction of the dopaminergic systems in the pathways that specifically link the sensory input and motor output. Keeping in mind that clinical symptomatology in RLS and cerebrospinal fluid dopamine...

Gopal, Y.N.Vashisht.; Rizos, H.; Chen, G.; Deng, W.; Frederick, D.T.; Cooper, Z.A.; Scolyer, R.A.; Pupo, G.; Komurov, K.; Sehgal, V.; Zhang, J.; Patel, L.; Pereira, C.G.; Broom, B.M.; Mills, G.B.; Ram, P.; Smith, P.D.; Wargo, J.A.; Long, G.V.; Davies, M.A., 2015: Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma. Metabolic heterogeneity is a key factor in cancer pathogenesis. We found that a subset of BRAF- and NRAS-mutant human melanomas resistant to the MEK inhibitor selumetinib displayed increased oxidative phosphorylation (OxPhos) mediated by the trans...

Anonymous, 1978: Breast lumps in adolescent girls. British Medical Journal 1(6108): 260-261

Temple, T.N.; Stockwell, V.O.; Johnson, K.B.; Loper, J.E., 2003: Iron bioavailability to Pseudomonas fluorescens strain A506 on pear and apple blossoms. Pseudomonas fluorescens strain A506 produces an antibiotic toxic to Erwinia amylovora in defined culture media containing at least 0.1mM FeCl3. To estimate the relative abundance of iron on blossoms, we used an iron biosensor (iron-regulated promo...

Ramachandran K.B.; Goma G., 1988: 2 3 butanediol production from glucose by klebsiella pneumoniae in a cell recycle system. Kinetics of 2,3-butanediol production by Klebsiella pneumoniae from glucose was studied in a cell recycle system with total recycle of biomass. Under these conditions productivity greater than batch or continuous system were obtained. However, whe...

Sackett, G.L., 1949: The role of the radiologist in mass chest X-ray survey. Radiology 53(2): 274-274