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Experimental cutaneous North American blastomycosis of hamsters

, : Experimental cutaneous North American blastomycosis of hamsters. Journal of Investigative Dermatology 45(6): 409-418

Active skin lesions, persisting in some animals for 6 months but without ulceration, were elicited in 75 percent of inoculated hamsters receiving yeast cells of B. dermatitidis subcutaneously. Simultaneous traumatic muscle damage did not produce significantly different reactions. Specific regional lymphadenitis, as part of the primary complex, was found in only 20 percent of the subcutaneously inoculated cases. This relatively low incidence could be in part due to the difficulties of locating lymph nodes. No conclusive hematogenous spread of the fungus was observed. Although an infection was achieved with as few as 10 yeast cells, an extremely high infective dose produced consistent primary complexes but without hematogenous dissemination. Challenged animals showed some protection in the absence of lymphadenitis. The results of the intratesticular route of infection are described and the presence of Schaumann bodies in granulomatous lesions discussed. The results of this experiment, if inferences regarding human infections are permitted, confirm good prognosis of human primary cutaneous blastomycosis. However, the lack of confirmed hematogenous dissemination in our series could be due to a low grade invasiveness of the strain used. The differences in experimental primary cutaneous infections with H. capsulatum and B. dermatitidis are discussed.


PMID: 5846996

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