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Experimental studies to guide the selection of the most satisfactory type of anti-welchii serum for the prevention and treatment of gas gangrene in man


, : Experimental studies to guide the selection of the most satisfactory type of anti-welchii serum for the prevention and treatment of gas gangrene in man. Indian Jour Med Res 26(2): 401-410

Groups of pigeons were injd. with different amounts of antitoxic and of antibacterial horse serum; then, one hour later, with a living bacterial suspension. In another set of exps., the pigeons received injections of living bacterial suspension three days after injs. of protective sera. The survival rates in different groups of pigeons showed that antitoxic serum alone can protect an animal against both an immediate and a delayed exptl. infection; and that the protection offered by an antitoxic serum is significantly better than that by an antibacterial serum, when compared volume to volume. In another exp. commercial anti-welchii sera were titrated against the 3 biological effects[long dash]hemolytic, necrotic and lethal[long dash]of the type A toxin. The result showed that they can neutralize all the effects of the toxin to an equal degree.

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