+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Failure Of Ethanol To Stimulate Incorporation Of Acetate-1-C14 Into Hepatic Fatty Acids In Vitro

, : Failure Of Ethanol To Stimulate Incorporation Of Acetate-1-C14 Into Hepatic Fatty Acids In Vitro. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine 115: 615-617

Ethanol and acetate at concentrations of 2.5,10 and 60 mmolar decrease the radioactivity of the liver slice fatty acids significantly below the level found in control experiments in which only 0.1 m[image] sodium acetate- 1-C14 was added. The suppressive effect of ethanol becomes maximal at 10 m[image] whereas that of acetate increases with the concentration and becomes maximal at 60 m[image], at which point the suppression becomes almost complete. These results show that the suppressing effect of ethanol on the incorporation by labeled acetate into hepatic fatty acid can be explained as being mostly due to isotopic dilution of labeled acetyl-CoA by unlabeled acetyl-CoA derived from ethanol. These results also show that the claim (Lieber and Davidson, Am. J. Med., 33, 319, 1962) that ethanol stimulates incorporation of acetate into fatty acids is based upon the interpretation of inadequately controlled experiments.


PMID: 14155777

DOI: 10.3181/00379727-115-28985

Other references

Gorrichategui, J.P., 1963: Use And Abuse Of The Word Vitamin New Water-Soluble Vitamin. A. Revista de la Sanidad Militar Argentina 62: 207-210

Kluczek, S.; Kluczek, J.-Piotr, 2008: Wplyw warunkow tuczu na aktywnosc wybranych enzymow krwi swin. The aim of the study was to evaluate changes in enzymatic activity taking place in the organisms of fattening pigs, located in two different places: with closed and opened runs-with their breeding conditions in accordance with animal husbandry st...

Votava, Z.; Beneova, O.; Bohdanecky, Z.; Soukova, M., 1963: Correlation between the EEG and behaviour effects of some thymoleptic drugs. BIOCHEM PHARMACOL 12(Suppl ): 57-58

Reddan, J.R.; Dziedzic, D.C.; Fleming, T.P.; Smith, D.A.; Andley, U.P., 1996: Identification of factors that stimulate and inhibit growth of cultured human lens epithelial cells. Investigative Ophthalmology & Visual Science 37(3): S985

Bayer, E., 1947: A capillary adsorption phenomenon of the serum pigment of the horse. When one end of a scrip of filter paper is Immersed for 24 hours in normal horse serum a yellowish brown band appears on the upper portion remote from the serum, comprised of albumin-bound bilirubin. The same phenomenon occurs with serum from haem...

Aukrust, P.; Ueland, T.; Aass, H.; Muller, F.; Andreassen, A.K.; Kjekshus, J.; Froland, S.S.; Simonsen, S.; Gullestad, L., 1997: Raised circulating levels of C-C chemokines in patients with chronic heart failure. Circulation 96(8 SUPPL ): I642, 10/21/97

Darby, C.M.; Ingólfsson, H.I.; Jiang, X.; Shen, C.; Sun, M.; Zhao, N.; Burns, K.; Liu, G.; Ehrt, S.; Warren, J.David.; Andersen, O.S.; Anderson, O.S.; Brickner, S.J.; Nathan, C., 2014: Whole cell screen for inhibitors of pH homeostasis in Mycobacterium tuberculosis. Bacterial pathogens like Mycobacterium tuberculosis (Mtb) encounter acidic microenvironments in the host and must maintain their acid-base homeostasis to survive. A genetic screen identified two Mtb strains that cannot control intrabacterial pH (p...

Agartz, I.; Sääf, J.; Wahlund, L.O.; Wetterberg, L., 1991: T1 and T2 relaxation time estimates and brain measures during withdrawal in alcoholic men. Twenty-four chronic alcoholic men were investigated with 0.02 Tesla/0.8 MHz magnetic resonance imaging on days 7-9 of acute alcohol withdrawal state. Estimates of T1 and T2 relaxation times were obtained from the white matter and basal ganglia nuc...

Pigoury, L.; Michel, C.; Chabassol, C., 1963: Epizootiology and prevention of tetanus in the principal animal species. Revue D'hygiene et de Medecine Sociale 11: 85-95

Bulusheva, K.; Ishchanov, R.; Khegai, V., 1981: Organizing the labor of machine operators in cotton cultivation. Trudy Vsesoiuznyi Ordena Lenina Nauchno Issledovatel'skii Institut Khlopkovodstva: 7) 65-68