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Gastroesophageal sphincteric pressures before and after oral anticholinergic drug and placebo administration

, : Gastroesophageal sphincteric pressures before and after oral anticholinergic drug and placebo administration. American Journal of Digestive Diseases 12(8): 823-833

Resting pressures in each 0.5-cm segment of the gastroesophageal sphincter were measured in 24 presumably healthy persons before and following 1 week's oral administration of an anticholinergic drug, valethamate bromide, 20 mg four times daily or a placebo of identical appearance. The double-blind technic was used with 12 subjects in each group. Pressures were detected by a 5- x 5-mm water-filled balloon and laterally notched, water-filled polyethylene tubes attached to extracorporeal transducers and measured at end inspiration and end expiration. No significant pressure alterations in either the open-tip or balloon tracings were recorded in the subjects who ingested valethamate bromide. In those who received the placebo, a decrease in open-tip pressures was recorded in the infrahiatal segments, the change being most apparent at end inspiration. Pressures registered by the balloon in the placebo group were not similarly altered.


PMID: 4951385

DOI: 10.1007/bf02236248

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