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Growth of virus in pigs immunized against the classic plague by living vaccines


, : Growth of virus in pigs immunized against the classic plague by living vaccines. Bull Acad Veterinaire France 38(3): 107-109

The lapinized virus is fixed and penetrated the receptive cells some hours after its injection. The state of resistance to experimental infection is established 4 to 5 days after the vaccination. At this time it is possible to isolate the virus vaccine from the organs of animals vaccinated. The lapinized virus does not compete against the wild virus if this last is inoculated with a short delay of 3 days, and the lapinized virus cannot be returned to show there where it has lost the competition. The dominance of the pathogenic virus can be explained by a much higher receptivity to this virus of sensitive cells facilitating its multiplication and dispersion and by a phenomenon of interference. These observations are in accordance with the results which were obtained in practice during the vaccinations of a herd in infected medium. They combine the explications that have resulted making the part of the animals already contaminated during the intervention among those of the vaccine sera eliminated and the part of the animals still endemic in which the serovaccination on the same sample vaccinated assures the resistance to infection under conditions where the wild virus does not penetrate the bodies during the 4 to 5 days following this vaccination.

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