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Increased sensitivity to penicillin and stroptomycin in medical personnel


, : Increased sensitivity to penicillin and stroptomycin in medical personnel. Vrachebnoe Delo 4: 127-128

To determine sensitivity to penicillin and stroptomycin, 23 intracutaneous tests were made in 15 medical workers having close contact with them. A positive allergic reaction was obtained in 4 (one to penicillin and 3 to streptomycin). Not a single one of the workers had had any allergic reactions in his past medical history. Two of them had previously been treated with antibiotics but the other 2 had not. The allergic reaction to streptomycin occurred in 5 hours and took the form of edema of the eyelids and a red, strongly exudative spot at the location of the intracutaneous test. All the manifestations disappeared within 24 hours. An allergic reaction to penicillin in 2 patients appeared within 1-2 minutes after administration and in another in 2 hours. They developed a burning sensation and the appearance of red spots like those of urticaria, hyperemia of the skin, brief weakness, and sweating. The spots disappeared in 30 minutes except in 1 patient in whom they lasted 1 day. The accomplishment of these tests can be used to prevent unforeseen in persons who come in contact with the antibiotics and in those treated with them.

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