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Irradiation as a cause of Masculinization in submaxillary glands

, : Irradiation as a cause of Masculinization in submaxillary glands. Brit Jour Exptl Pathol 42(1): 38-42

Male and female young Sprague-Dawley rats were sacrificed one year after 500 r total-body X-irradiation. Radiation affected both acini and tubules of the submaxillary glands, with most pronounced changes occurring in females. Irradiation masculinized the female submaxillary glands. The tubules were enlarged and the epithelial cells hypertrophied, due to hormonal imbalance and/or ovarian injury. The degree of masculinization (the number of acidophilic granules in the epithelial cells and the diameter of the tubules) can be used as an index of hormonal imbalance to evaluate ovarian function in rats and mice.


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