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Mechanisms for the liberation of histamine and 5-hydroxytryptamine during the anaphylactic reaction and under the action of histamine liberating substances in the rat


, : Mechanisms for the liberation of histamine and 5-hydroxytryptamine during the anaphylactic reaction and under the action of histamine liberating substances in the rat. J Arch Int Pharmacodyn Therap 147(3/4): 431-449

Two main techniques were used: the isolated skin "in vitro" and the perfused posterior train. The results obtained were quite similar with both techniques. The kinetics of histamine liberation are parallel during the anaphylactic reaction and after administration of dextran; when p-methoxyphenethylmethylamine condensation product with formaldehyde (48/80) was used, the histamine release was more prompt, more intense and more prolonged. The anaphylactic reaction brings about a release of 5-hydroxytryptamine (5-HT) the kinetics of which are parallel to those of histamine. The ratio [image]. The liberation of histamine 5-HT by anaphylactic reaction and dextran is very much thermo-sensitive: it is maximal at 34[degree]C; it decreases at 39[degree]C and it ceases practically at 15[degree]C. The release of histamine produced by 48/80 is only affected by much lower temperatures, close to 4[degree]C. The liberation of histamine by anaphylactic reaction and dextran is also more sensitive to the inhibitory action of monoiodoacetic acids than this caused by 48/80. The discrepancies observed in the patterns of histamine release in these various conditions suggest that chain of reactions, leading to this process, are identical for anaphylaxis and long chain macromolecules (dextran, ovomucoid, polyvinylpyrrolidone (PVP)) but different for 48/80.

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