geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Metabolism of iodomethane in the rat


, : Metabolism of iodomethane in the rat. Biochemical Journal 98(1): 38-43

1. The LD(50) of iodomethane orally administered to rats is 76mg./kg. body wt. but repeated daily doses of 30-50mg./kg. body wt. are without effect. 2. Oral doses of iodomethane to rats are rapidly converted into S-methylglutathione in the liver, and S-methylglutathione is excreted in the bile. 3. The conjugation process has been reproduced in vitro and shown to be enzymically catalysed. 4. S-Methylglutathione is degraded to S-methylcysteine by kidney homogenates. 5. Only a small proportion of a dose of iodomethane or of S-methylcysteine is excreted as compounds related to methylmercapturic acid. 6. Paper chromatography of extracts of livers from normal and dosed rats supports the view that GSH is the predominant non-protein thiol present.

US$29.90

PMID: 5938661


Other references

Hutson, T.E.; Al-Shukri, S.; Stus, V.P.; Lipatov, O.N.; Shparyk, Y.; Bair, A.H.; Rosbrook, B.; Andrews, G.I.; Vogelzang, N.J., 2016: Axitinib Versus Sorafenib in First-Line Metastatic Renal Cell Carcinoma: Overall Survival From a Randomized Phase III Trial. In a randomized phase III trial in treatment-naive patients with metastatic renal cell carcinoma (RCC), axitinib versus sorafenib yielded numerically longer progression-free survival (median, 10.1 vs. 6.5 months; hazard ratio [HR], 0.77; 1-sided P...

Abe, K., 2013: Introduction: Taste perception. Seminars in Cell & Developmental Biology 24(3): 199-199

Lazarov, N.E.; Reindl, S.; Fischer, F.; Gratzl, M., 2009: Histaminergic and dopaminergic traits in the human carotid body. Carotid body (CB) chemoreceptors are the main sensors detecting systemic hypoxia. Studies in animals revealed that dopamine and histamine may serve as transmitters between the chemoreceptor cells and the afferent nerve. To gain insight whether his...

Fraser L.; Matthews R.E.F., 1979: Strain specific pathways of cytological change in individual chinese cabbage protoplasts infected with turnip yellow mosaic virus. Two mutually exclusive pathways of cytological change in the chloroplasts of Chinese cabbage cells infected with turnip yellow mosaic virus were defined by light microscopic examination of individual infected protoplasts. In the first, all the chl...

Hallden, N.A.; Fisenne, I.M., 1963: Minimizing Self-Absorption In 4 Pi Beta-Counting. International Journal of Applied Radiation and Isotopes 14: 529-532

Reiter, H.; Reissmann, W., 1928: Lipoids and metabolism. N excretion is increased on a diet deficient in lipoids. A normal N excretion is promptly reestablished when lipoids are added to the diet. Lipoids spare protein.

Ashman, F.; Higgs, G.A., 1968: A horned strain of Oryzaephilus surinamensis L Coleoptera, Silvanidae from the Mediterranean Region. The small and large strains of Oryzaephilus surinamensis (L.) described by Aitken (1966) have been compared with a bicornis strain from the Mediterranean region. Only the latter possessed the bicornis character which was only visibly expressed in...

Nikol'-Skii, S.; Slipchenko, S., 1969: Experiments in the transmission of Eperythrozoon ovis by the ticks Hyalomma plumbeum and Rhipicephalus bursa. Veterinariia 5 46

Penberthy, L.T.; Towne, A.; Garnett, L.K.; Perlin, J.B.; DeLorenzo, R.J., 2005: Estimating the economic burden of status epilepticus to the health care system. Status epilepticus (SE) is a major neurological condition associated with significant morbidity and mortality. No studies to evaluate the cost burden of SE have been performed to date. This study estimates the direct cost related to an inpatient a...

Levine, Alexandra M., 1994: Clinical aspects of AIDS-related lymphoma. Proceedings of the American Association for Cancer Research Annual Meeting 35(0): 660-661