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Observations of circulatory physiology in a case of isolated ventricular septal defect


, : Observations of circulatory physiology in a case of isolated ventricular septal defect. Rev Beige Path Et Med Exptl 19: 175

Catheterization of the right heart and of the pulmonary artery was performed in a case of isolated ventricular septal defect. Gas analyses of samples secured from right auricle, right ventricle and pulmonary artery were sufficient for the diagnosis since the O2 content in the right ventricle and of pulmonary artery exceeded that of right auricle by 3 vols. %. Calculations of cardiac output showed the blood flow in the pulmonary artery to be twice as large as that in the aorta. The blood flow through the ventricular septal defect was equal to that in the aorta. The coexistence of secondary right to left ventricular shunts was proved by two findings: the O2 saturation of the blood in the femoral artery was lower (92%) than normal, and the effective pulmonary artery flow was 11.5% below that of the systemic circulation. Pulmonary stenosis did not exist because the mean blood pressure was higher in the pulmonary artery than in the right ventricle; the absence of pulmonary stenosis was also proved by the fact that the pulmonary blood flow was 200% of the systemic blood flow.

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