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Observations On Experimental Shock


, : Observations On Experimental Shock. British Medical Journal 1(3832): 1070-1072

Experimental shock was produced in dogs, anesthetized with Na barbiturate, by traumatizing one hind limb. There was no evidence of any depressor substance in the blood of the femoral or iliac vein of the traumatized limb. In no expt. was the blood pressure reduced to a shock level unless there was a loss of plasma and blood into the injured tissues, sufficient in itself to account for the effects observed. The evidence against the "traumatic toxemia" or histamine theory of secondary shock is reviewed and accepted. Recent American work, showing that the lowered blood volume in shock is due to the loss of blood and plasma into the traumatized area, is confirmed.

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PMID: 20778337


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