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On the metabolic equivalence of deuterium and tritium in animal experimentation


, : On the metabolic equivalence of deuterium and tritium in animal experimentation. Archives of Biochemistry and Biophysics 42(1): 219-220

Four rats were injd. intraperit. with sufficient D2O (92.5%) to bring the concn. in body water to approx. 5%. The injd. soln. also contained 0.9% NaCl and approx. 1 mc./ml. HTO. Two additional injns. of half the original quantity were given at 3.5-day intervals. 3 days after the last injns. the animals were sacrificed. The retention ratios were very close to unity, indicating similar metabolic behavior of deuterium-labelled and tritium-labelled compounds.

US$19.90

PMID: 13031625

DOI: 10.1016/0003-9861(53)90255-0


Other references

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