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On the site of antitussive action of l- -2-piperidinopropane phosphate


, : On the site of antitussive action of l- -2-piperidinopropane phosphate. Jap J Pharmacol 17(4): 538-549

The antitussive activity of the drug is approximately equal to that of codeine in dogs and cats. When the drug was administered through 3 routes such as the common carotid artery, the vertebral artery and the cerebello-medullary cistern, much smaller doses produced the same effect as intravenous administration; the ratio in equi -active doses shown by the administration of the drug by 4 routes was different from that of codeine, which acts exclusively on the cough center. A larger dose was necessary to depress the centrally-evoked cough than to depress the cough responses peripherally induced by mechanical or electrical stimulation. In the cat, the stretch receptor impulses were not affected with an antitussive dose (2.5 mg/kg); they were decreased or abolished when the dose was increased to 7.5 or 10 mg/kg. In guinea pig, similar effects were observed. The drug showed spasmolytic actions on the bronchial muscles in rabbits (in vivo) and on the tracheal muscles in guinea pigs (in vitro). The effect of the drug was not influenced by decerebration after mid-collicular transection. The drug showed no effect on the efferent respiratory pathways extending from the spinal cord to the respiratory muscles. The antitussive activity is displayed mainly through the decrease in excitability of the cough center and partly through peripheral effects such as the decrease of pulmonary stretch receptor impulses and the relaxation of the bronchial muscles. The mode of depressing action of the drug on the cough center was different from those of narcotic antitussive agents such as codeine, because the antitussive activity of the drug is not antagonized by N-allylnormor-phine.

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