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Pharmacology of folic acid antagonists as related to brain and cerebrospinal fluid

, : Pharmacology of folic acid antagonists as related to brain and cerebrospinal fluid. Cancer ChemoTherapy Reports 16: 187-190

Folic acid and its analogs in general are excluded from the cerebrospinal fluid after systemic administration. When administered intrathecally, both Methotrexate and aminopterin caused convulsions in dogs at a dose of about 1 mg./kg. Aminopterin is more potent as a folic acid antagonist and severe systemic toxicity follows this compound at this dosage. This systemic toxicity was prevented when citrovorum factor was given systemically in divided dosage at 5 times the dose of aminopterin.


PMID: 14490033

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