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Pian in Brazil


, : Pian in Brazil. Bull Soc Path Exotique 21(5): 387-400

The author discusses the general etiology and pathology of pian, stressing ways of distinguishing it from other diseases, especially syphilis. He found no age limit, although it is more common in children; immunity conferred by infection, but no congenital immunity; no hereditary transmission; no racial difference in distribution. No morphological differences between Trypanosoma pertenue and T. pallidum were noted but the distribution of the organisms in lesions was diagnostically important. Experimentally, superinfections were possible during the incubation period, which was 38 days in monkeys and 56 in rabbits inoculated intratesticularly. He is in accord with earlier workers as to the leucocytic formula[long dash]a mononucleosis, a more or less accentuated eosin-ophilia (possibly due to intestinal worms) and a diminution of lymphocytes. The Bordet-Wassermann test was always positive in the eruptive period and negative after treatment, except with cerebrospinal fluid, when it was constantly negative (an interesting point in the differential diagnosis of pian and syphilis). Good results followed treatment with potassium and sodium iodide, neosalvarsan and similar products, sulfarsenol, acetylarsan, stovarsol, treparsol and bismuth preparations; exceptionally good results followed 606 and 914.

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