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Postepidemic diagnosis of yellow fever by the passive immunity test


, : Postepidemic diagnosis of yellow fever by the passive immunity test. Jour Prevent Med 4(6): 459-462

This test furnishes experimental evidence that yellow fever has occurred in recent years in Colombia, South America. While it is impossible to say when individuals containing protective antibodies actually had yellow fever, it can be reasonably conjectured that the attacks occurred at the time they were ill with a disease suspected of being yellow fever,[long dash]i.e., in Bucaramanga, in 1910 and 1923, and in Guadalupe and Socorro, in 1929. Failure of 3 specimens to protect monkeys against the virus suggests the difficulty of making a definite diagnosis of yellow fever in mild cases, while the agreement of the test with the diagnosis in recently observed cases shows the thoroughness with which the Socorro epidemic was analyzed. The passive immunity test proved applicable to the study of the nature of outbreaks clinically suggesting yellow fever, and confirmed the existence of yellow fever in a region previously considered free. Since a strain of virus from West Africa was used, yellow fever in yet another part of South America is shown to be immunologically identical with that of West Africa.

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