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Preliminary experiences with transplants of cultured parathyroid tissue in hypoparathyroidism

, : Preliminary experiences with transplants of cultured parathyroid tissue in hypoparathyroidism. Annals of Internal Medicine 46(4): 649-661

Living parathyroid tissue was implanted on 14 occasions in 11 patients with surgical hypoparathyrodism. Implants were prepared using fetal parathyroids and later parathyroid adenomas. Fragments 1 mm or less in diameter were grown in tissue culture and gradually adapted to the recipient's serum before the implant. At each implant 13-80 fragments were placed in the sheath of the axillary vein. In 2 of the 11 patients the implants were successful. In one patient who had previously been extremely resistant to antitetanic therapy, a transplant of fetal tissue remained functional for 9 to 10 months; a second transplant of adenomatous tissue in the same patient gave "partial relief" of subjective symptoms for 13 months. In a second patient relief has persisted for 19 months to date following transplant of adenomatous tissue. In 6 other patients implants gave transient relief for periods of 1 to 6 weeks. In the remaining 4 patients there was no improvement.


PMID: 13411874

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