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Preparation and antitumor activity of tris phosphine oxide 1,2


, : Preparation and antitumor activity of tris phosphine oxide 1,2. Cancer Chemother Rep 51(5): 253-259

A method is described for the synthesis of tris(2,2-dimethyl-l-aziridinyl) phosphine oxide (TEPA-132). Acute toxicity and therapeutic effect of this compound were studied in several transplanted rodent tumors. Optimal doses and conditions produced 100% cure rate in Adenocarcinoma 755 and 50-90% cure rate in leukemia L1210, leukemia P1534, and Dunning leukemia ICR741. Growth of Sarcoma 180 was inhibited about 50% by optimal doses, but no cures were observed. The Ehrlich adenocarcinoma was inhibited about 80-99% by optimal doses. Therapeutic indices for some of the tumor systems, when they could be estimated, were about 2.

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Lee, Y-Cheng.; Wang, Y-Che.; Chien, C-Hung.; Wu, C-Huei.; Lu, S-Chiung.; Tsai, S-Bing.; Dong, W., 2016: Applying revised gap analysis model in measuring hotel service quality. With the number of tourists coming to Taiwan growing by 10-20 % since 2010, the number has increased due to an increasing number of foreign tourists, particularly after deregulation allowed admitting tourist groups, followed later on by foreign i...

Gordon, D.S.; Sergeeva, V.E.; Zelenova, I.G., 1979: Functional morphology of the adrenergic innervation and adrenocontaining structures of the lymphoid organs. Topography of adrenergic neural fibres and adrenodependent structures in lymphoid organs of some mammals (rat, cat, dog, guinea-pig, golden hamster) has been studied by means of Falck's method with other histochemical methods applied simultan...

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L.Cava, A., 2008: T-regulatory cells in systemic lupus erythematosus. Thymus-derived CD(4+)CD25(high)Foxp(3+) T-regulatory cells (Tregs) have an important role in the mechanisms of peripheral immune tolerance and in the prevention of pathogenic autoimmunity through the suppression of proliferation and production of...

Wetsel, O.; Brandt, R.; Hustedt, F., 1935: Die Mikropalaeontologie des Heiligenhafener Kieseltones (Ober-Eozan). Mitt Roemer mus, 38: 41-75

Barnaba, C.; Dellacassa, E.; Nicolini, G.; Nardin, T.; Malacarne, M.; Larcher, R., 2016: Identification and quantification of 56 targeted phenols in wines, spirits, and vinegars by online solid-phase extraction - ultrahigh-performance liquid chromatography - quadrupole-orbitrap mass spectrometry. Phenolic compounds seriously affect the sensory and nutritional qualities of food products, both through the positive contribution of wood transfer in barrel-aged products and as off-flavours. A new targeted analytical approach combining on-line s...

Dahlkamp F.J., 1989: Classification scheme for uranium ore deposits; a state of the art review. Panel Proceedings Series - International Atomic Energy Agency 1989: 1-31

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