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Pulmonary diffusing capacity and its subdivisions in polycythemia vera

, : Pulmonary diffusing capacity and its subdivisions in polycythemia vera. Journal of Clinical Investigation 42: 997-1006

Pulmonary diffusion capacity (DL) was measured by breath-holding carbon monoxide method in 10 patients with polycythaemia vera. Measurements were made at 3 levels of alveolar oxygen tension permitting estimates of the diffusing capacity of the pulmonary membrane (DM) and the pulmonary capillary blood volume (Vc). DL was greater than normal in all patients, but fell after treatment with P32, often to subnormal values. Vc corrected for hemoglobin concentration was less than normal and did not change after treatment. DM varied widely and showed no trend. Physiological dead space was sometimes increased. It is suggested that DL was elevated due to the increased hemoglobin concentration. It is postulated that the reduction of Vc may have been due to thrombosis of small pulmonary arteries, this process limiting the increase in DL.


PMID: 14016987

DOI: 10.1172/JCI104804

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