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Relation between PAH extraction and the maximum tubular load for PAH

, : Relation between PAH extraction and the maximum tubular load for PAH. Pflugers Arch Gesamte Physiol Mens Tiere 284(1): 18-30

Secretion of PAH was determined in the dog (i) in normal conditions, (ii) in post-hemorrhagic hypotension and (iii) in severe dehydration, respectively. TmPAH amounted to (i) 12.0, (ii) 3.9 and (iii) 6.1 mg/min/100 g kidney weight, respectively. Maximal extraction ratios were (i) 0. 81, (ii) 0.79 and (iii) 0. 68. The ratio renal plasma flow/TmpAD was the same in the three sets of experiments; 17. 3, 16. 2 and 16. 87 respectively. The radio glomerular filtration rate/TmpAH amounted to 3. 63, 1. 07 and 1. 80, respectively; its value is diminished in the pathological series. The maximal extraction ratios of PAH are correlated to the variations of TmPAH-values and to the splay of the titra-tion curves of PAH. Even with much dimished TmPAH values normal maximal extraction ratios can be found, if the tubular load of PAH amounts to a fraction of TmPAH only, i. e. the ratio load PAH/TmPAH is kept low.


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