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Requirements of new antitubercular drugs from the experimental point of view


, : Requirements of new antitubercular drugs from the experimental point of view. Annals of the New York Academy of Sciences 106: 78-84

Only isoniazid corresponds to theoretical and practical requirements with respect to tolerance and efficacy in tuberculosis treatment. At least 2 more preparations which equal or surpass isoniazid and possess a different mechanism of action are needed. Isoniazid is recommended as a standard preparation, but other drugs against tubercle bacilli of the human type highly resistant to isoniazid. are needed. For chemoprophylaxis, outpatient treatment of mild cases and follow-up treatment injectable long-acting preparations are needed which can be administered at intervals of 1-2 wks. These are particularly needed in countries where medicine and hygiene are still primitive.

US$19.90

PMID: 13945937

DOI: 10.1111/j.1749-6632.1963.tb16625.x


Other references

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Santos-Sacchi, J., 2008: Cochlear mechanics: no shout but a twist in the absence of prestin. Mammalian hearing is boosted by mechanically active auditory receptor cells, the outer hair cells which amplify the actions of incoming sounds. Recent evidence indicates that the molecular motor that drives this amplification, prestin, may do more...

Litav, M.; Kupernik, G.; Orshan, G., 1963: The role of competition as a factor in determining the distribution of dwarf shrub communities in the Mediterranean territory of Israel. Competition by annuals plays an important role in the distribution of dwarf shrubs. It was found that Avena sterilis, the most common annual in the Mediterranean territory of Israel, strongly inhibits the development of young seedlings of Poterium...

Sankaranarayanan, R.; Venetucci, L., 2012: Are the anti-arrhythmic effects of omega-3 fatty acids due to modulation of myocardial calcium handling?. Both animal and clinical studies have demonstrated that omega-3 fatty acids have anti-arrhythmic properties. It has been suggested that these anti-arrhythmic effects are due to modulation of the activity of various myocardial calcium handling prot...

Yee, L.E.; Reiter, J.F., 2015: Ciliary vesicle formation: a prelude to ciliogenesis. Reporting recently in Nature Cell Biology, Lu et al. (2015) identify two Eps15-homology-domain-containing proteins as critical effectors of ciliary vesicle formation, an early event in ciliogenesis. Functional dissection reveals that one of them w...

Guze, S.B., 1975: The validity and significance of the clinical diagnosis of hysteria (Briquet's syndrome). The author states that a valid diagnostic classification based on the medical model is a sine qua non for progress in psychiatric research and treatment and that such classification requires follow-up and family studies. To illustrate this point h...

Zwillich C.W.; Martin B.; Rose C., 1980: Relative cardio selectivity of beta blockade with propranolol. Clinical Research 28(1): 20A

Jin, Z.; Lin, Y.; Huang, D.; Su, G.; Han, S., 2011: Synthesis of flavor esters catalyzed by CALB-displaying Pichia pastoris whole-cells in non-aqueous phase. An enzyme-displaying yeast as a whole-cell biocatalyst seemed an alternative to immobilized enzyme, due to its low-cost preparation and simple recycle course. Here, we tried to use a recombinant Pichia pastoris displaying Candida antarctica lipase...

Yan, S.L.; Chu, Y.C., 2007: Hookworm infestation of the small intestine: an unusual cause of obscure gastrointestinal bleeding. Endoscopy 39 Suppl 1: E162-E163

Schmidt, R.; Conrad, D.; Field, E.; O'Reilly, R., 2015: Management of First Branchial Cleft Anomalies via a Cartilage-Splitting Technique. First branchial cleft anomalies are uncommon lesions that often present as periauricular infections. They have high recurrence rates, due in part to scarring secondary to prior infections and their management. These lesions have a close relationsh...