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Requirements of new antitubercular drugs from the experimental point of view

, : Requirements of new antitubercular drugs from the experimental point of view. Annals of the New York Academy of Sciences 106: 78-84

Only isoniazid corresponds to theoretical and practical requirements with respect to tolerance and efficacy in tuberculosis treatment. At least 2 more preparations which equal or surpass isoniazid and possess a different mechanism of action are needed. Isoniazid is recommended as a standard preparation, but other drugs against tubercle bacilli of the human type highly resistant to isoniazid. are needed. For chemoprophylaxis, outpatient treatment of mild cases and follow-up treatment injectable long-acting preparations are needed which can be administered at intervals of 1-2 wks. These are particularly needed in countries where medicine and hygiene are still primitive.


PMID: 13945937

DOI: 10.1111/j.1749-6632.1963.tb16625.x

Other references

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Santos-Sacchi, J., 2008: Cochlear mechanics: no shout but a twist in the absence of prestin. Mammalian hearing is boosted by mechanically active auditory receptor cells, the outer hair cells which amplify the actions of incoming sounds. Recent evidence indicates that the molecular motor that drives this amplification, prestin, may do more...

Litav, M.; Kupernik, G.; Orshan, G., 1963: The role of competition as a factor in determining the distribution of dwarf shrub communities in the Mediterranean territory of Israel. Competition by annuals plays an important role in the distribution of dwarf shrubs. It was found that Avena sterilis, the most common annual in the Mediterranean territory of Israel, strongly inhibits the development of young seedlings of Poterium...

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