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Some considerations of the antigen dose-antibody response relationship

, : Some considerations of the antigen dose-antibody response relationship. Journal of Immunology 76(3): 187-191

Data derived from the literature are presented in support of the 1912 theory of Smith and St. John-Brooks that the antigen dose-antibody response follows the form: K1c1/n=Ab where K1 is a constant, c is the concentration of the antigen, n is a constant between 1.9 and 3.6 and Ab is the maximum concentration of antibody. The value of n appears to depend upon the chemical composition of the antigen. For proteins, n is about 1.9, for lipopolysaccharides about 2.6, and for polysac-charides about 3.6. From limited data, this equation appears to hold only at intermediate concentrations of antigen. At low concentrations, n approaches 1, while at high concentrations n approaches infinity. On the basis of the above equation, certain values for K1 could be calculated, and these are listed. These findings are consistent with, but do not prove, the concept that the limiting step in antibody production involves an adsorption process.


PMID: 13306953

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