geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Structured timing patterns within bursts from epileptic neurons inundrugged monkey cortex


, : Structured timing patterns within bursts from epileptic neurons inundrugged monkey cortex. Exp Neurol 21(4): 535-549

While normal cortical neurons often show ill-defined, labile bursts during spontaneous firing, stereotyped high-frequency bursts every 50-200 msec are characteristic of the firing patterns of neurons near chronically alumina-induced epileptic foci in sensorimotor cortex of awake, undrugged rhesus monkeys. Computer-assisted analysis of the timing patterns within bursts revealed an unusually long interval between the first and 2nd spikes of these epileptic bursts, with the later spikes of the burst time-locked to the 2nd spike, not the first spike. In some neurons, this stereotyped "remainder" of the burst would begin at a highly variable time following the first spike. In other neurons, this first interval was bimodal, with the remainder of the burst starting either 3 or 4 msec following the first spike. In a 3rd class of epileptic neuron, the first interval was unusually long and remarkably lacking in variability (8.6 [plus or minus] 0.2 msec). Other neurons, especially those located further away from the epileptogenic focus, showed less stereotyped bursts without the long first intervals. One explanation considered for these phenomena is that the neuron is being stimulated anti-dromically (first spike) and responds repetitively (remainder of the burst).

US$29.90

PMID: 4971107


Other references

Takei F., 1983: Early t cell differentiation antigen expressed on mouse t leukemia cell lines. Journal of Cellular Biochemistry Supplement (7 PART B): 48

Chew, M.H.; Chiow, A.; Tang, C.L., 2008: Keloid formation after stapled haemorrhoidectomy causing anal stenosis: a rare complication. Techniques in Coloproctology 12(4): 351-352

Lipsitt, Lewisp, 1967: The concepts of development and learning in child behavior. Ucla [untv Calif Los Angeles] Forum Med Sci 6 : 211-248

Klein, G.; Behne, M.; Probst, S.; Dudziak, R.; Forster, H.; Asskali, F., 1990: Life-threatening lactic acidosis during total parenteral nutrition: successful treatment with thiamin. Severe metabolic acidosis developed in 2 women, 37 and 44 years old, given total parenteral nutrition for 3 weeks after abdominal surgery. Sepsis, peritonitis or hypoxia was not implicated. Serum lactate reached 24.3 and 22.8 mmol/litre. Treatment...

Velleman, Y.; Wilson-Jones, M., 2017: Vaccines plus water, sanitation, and hygiene interventions in the fight against cholera. Lancet. Global Health 5(4): E394-E394

Lavrentovich D.I.; Grigoruk V.P., 1974: Effect of fertilizers on the yield and quality of corn and soybeans grown in pure and mixed sowings. Naukovi Pratsi Ukrayins'ka Sil's'kohospodars'ka Akademiya 113: 53-56 (FROM REF ZH RASTENIEVOD BIOL OSN OTD VYP, 1975, 4

Benton D., 1984: The long term effects of naloxone di butyryl cyclic cmp and chlorpromazine on aggression in mice monitored by an automated device. A device that records that squeaks of attacked mice, used in combination with a microcomputer, was evaluated as a means of monitoring fighting over extended periods. The influences of chlorpromazine, naloxone and dibutyryl cCMP were monitored for...

Charytan, C.; Purtilo, D., 1969: Glomerular capillary thrombosis and acute renal failure after epsilon-amino caproic acid therapy. New England Journal of Medicine 280(20): 1102-1104

Tanzer, J.M., 1987: The microbiology of the oral cavity. Current research issues and future developments. Deutsche Zahnarztliche Zeitschrift 42(10 Suppl 1): S45-S53

Britton, A.; Shipley, M.; Marmot, M.; Hemingway, H., 2004: Does access to cardiac investigation and treatment contribute to social and ethnic differences in coronary heart disease? Whitehall II prospective cohort study. Objective To determine whether access to cardiac procedures and drugs contributes to social and ethnic differences in coronary heart disease in a population settmg. Design Prospective study with follow up over 15 years. Civil service employment gr...