+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Studies with cytarabine HCL in normal eyes of man, monkey and rabbit

, : Studies with cytarabine HCL in normal eyes of man, monkey and rabbit. Amer J Ophthalmol 60(6): 1074-1082

No indications of toxicity were seen in eyes of albino rabbits or humans treated topically 6 times daily for 6-10 days with 0. 1% cytarabine hydrochloride (CA) ophthalmic preparations, but use of 0. 5-1% CA was associated with speckling of rabbit, monkey and human corneas which resembled fine dust particles as seen on retro illumination with the biomicroscope. Histologic study in rabbit and monkey eyes revealed thinning and distortion of the corneal epithelium, with degeneration of individual corneal epithelial cells. Lesions were restricted to the corneal epithelium and were dose-related. Treated corneas returned to normal after the drug was discontinued. Results of repeated intermittent treatment in rabbits indicate that CA is not likely to produce increased tissue sensitivity.


PMID: 4955208

Other references

Karimi, S.; Jahanshahi, M.; Golalipour, M.J., 2015: The effect of MDMA-induced anxiety on neuronal apoptosis in adult male rats' hippocampus. Ecstasy or MDMA as a psychoactive drug and hallucinogen is considered one of the most commonly used drugs in the world. This psychotropic substance is discussed both as sexually stimulating and reducing fear and anxiety. Amphetamines also destroy...

Dunn, J.P., 2004: Review of immunosuppressive drug therapy in uveitis. Uveitis is an important cause of functional visual loss and blindness in the developed world. Immunosuppressive drugs may be required to treat severe noninfectious uveitis successfully, but the efficacy and safety of such treatments are often limi...

Likhterman, B.V.; Kunitsyna, L.A., 1967: Sanatorium-health resort treatment of patients with neurasthenia with functional cardiovascular disorders. Vrachebnoe Delo 8: 21-24

Gill, L.S., 1978: Chromosome numbers of angiosperms in tanzania part 2. Chromosome numbers of 27 spp. are reported. Of these, chromosome counts for 9 spp. [Anthericum brehmerianum, Chlorophytum filipendulum, C. carsonii, Drimiopsis volkensii, Thespesia danis, Ceriops tagal, Leucas martinicensis, Psychotria swynnertoni...

Zhao, H.; Neamati, N.; Mazumder, A.; Sunder, S.; Pommier, Y.; Burke, T.R., 1997: Arylamide inhibitors of HIV-1 integrase. Based on data derived from a large number of HIV-1 integrase inhibitors, similar structural features can be observed, which consist of two aryl units separated by a central linker. For many inhibitors fitting this pattern, at least one aryl ring a...

Cronberg, S.; Wallmark, E.; Söderberg, I., 1984: Effect on platelet aggregation of oral administration of 10 non-steroidal analgesics to humans. Platelet aggregation was investigated in platelet-rich plasma from normal volunteers before and at various times after intake of 10 analgesic drugs. The drugs used were aspirin, piroxicam, naproxen, indomethacin, diclofenac, ibuprofen, diflunisal,...

Mortvedt, J.J., 1962: The effect of manganese and copper on the growth of Streptomyces scabies and the incidence of Potato scab. In field experiments at Univ. Wis. high rates of MnSO4 (150 and 450 lb./acre) significantly reduced scab, broadcasting 150 lb. in a 12 in. band near the tubers being more effective than placing it in the fertilizer band. In nutrient culture experi...

Aimoto, T.; Uchida, E.; Matsushita, A.; Tabata, Y.; Takano, T.; Miyamoto, M.; Tajiri, T., 2007: Controlled release of basic fibroblast growth factor promotes healing of the pancreaticojejunal anastomosis: a novel approach toward zero pancreatic fistula. Background. Several reconstructive surgical techniques have been proposed for restoring pancreaticojejunal continuity. Little has been done, however, to evaluate the efficacy of tissue engineering on anastomotic healing. We examined the effects of...

D.Silva Lacaz, C., 1955: Present data on blood groups. Resenha Clinico-Cientifica 24(5): 114-118

Kostin, I.; Kosova, L.; Balykina, L.; Gvozdiuk, T., 1973: Cereal crops under irrigation. Gidrotekhnika i melioratsiia: 11 65-68